Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	INPP4A
Previous Symbol	INPP4
Approved Name	inositol polyphosphate-4-phosphatase, type I, 107kDa
Previous Name	inositol polyphosphate-4-phosphatase, type I, 107kD
Location	2q11.2
Position	chr2:98444854-98594390, 1
External Links	HGNC: 6074 Entrez Gene: 3631 Ensembl: ENSG00000040933 UCSC: uc002syy.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Goes, F. S.,2012	SNP: rs12617721	OR = 1.2,P-value(Meta) = 0.00000745 Suggestive association was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

GO terms by PBA (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006644	phospholipid metabolic process	biological process	TAS	18
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	biological process	IEA	5
GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	molecular function	IEA	1
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS	13
GO:0005829	cytosol	cellular component	TAS	223
GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	molecular function	IEA	1
GO:0007165	signal transduction	biological process	TAS[7608176]	136
GO:0043647	inositol phosphate metabolic process	biological process	TAS	7
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0016311	dephosphorylation	biological process	IEA	14

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00562	Inositol phosphate metabolism	11
hsa04070	Phosphatidylinositol signaling system	16

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
INPP4A	SMAD1	NO	yeast 2-hybrid	15231748
INPP4A	CAPN1	NO	in vitro;in vivo	9110986

Related other genetic factors

Gene related SNPs (count: 70)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs12617721	chr2:98467429 - 98467429(1)	intron_variant	1(0/0/1)

LD-proxies (count: 69)

rs_ID	Location	Functional Annotation
rs3769743	chr2:98447190 - 98447190(1)	intron_variant
rs12618524	chr2:98447566 - 98447566(1)	intron_variant
rs4851136	chr2:98444410 - 98444410(1)	upstream_gene_variant
rs3754892	chr2:98446855 - 98446855(1)	intron_variant
rs3769741	chr2:98451741 - 98451741(1)	intron_variant
rs3769740	chr2:98452745 - 98452745(1)	intron_variant
rs4851138	chr2:98449001 - 98449001(1)	intron_variant
rs10496327	chr2:98450364 - 98450364(1)	intron_variant
rs17031905	chr2:98454439 - 98454439(1)	intron_variant
rs17444095	chr2:98459354 - 98459354(1)	intron_variant
rs4850874	chr2:98453336 - 98453336(1)	intron_variant
rs4850875	chr2:98453352 - 98453352(1)	intron_variant
rs3754891	chr2:98471555 - 98471555(1)	intron_variant
rs3769737	chr2:98472410 - 98472410(1)	intron_variant
rs3769738	chr2:98461904 - 98461904(1)	intron_variant
rs17032120	chr2:98466475 - 98466475(1)	intron_variant
rs3769734	chr2:98479686 - 98479686(1)	intron_variant
rs3769735	chr2:98475839 - 98475839(1)	intron_variant
rs3769729	chr2:98486347 - 98486347(1)	intron_variant
rs3729568	chr2:98483733 - 98483733(1)	intron_variant
rs3769727	chr2:98486855 - 98486855(1)	intron_variant
rs3769728	chr2:98486538 - 98486538(1)	intron_variant
rs3769725	chr2:98489504 - 98489504(1)	intron_variant
rs3769726	chr2:98489364 - 98489364(1)	intron_variant
rs4850877	chr2:98495691 - 98495691(1)	intron_variant
rs3754886	chr2:98491214 - 98491214(1)	intron_variant
rs3820943	chr2:98506714 - 98506714(1)	intron_variant
rs3754885	chr2:98505245 - 98505245(1)	intron_variant
rs3769717	chr2:98508354 - 98508354(1)	intron_variant
rs3769719	chr2:98507941 - 98507941(1)	intron_variant
rs12619665	chr2:98510088 - 98510088(1)	intron_variant
rs3754884	chr2:98508913 - 98508913(1)	intron_variant
rs11901568	chr2:98512158 - 98512158(1)	intron_variant
rs6753380	chr2:98512577 - 98512577(1)	intron_variant
rs11902825	chr2:98512674 - 98512674(1)	intron_variant
rs3754883	chr2:98512988 - 98512988(1)	intron_variant
rs11884553	chr2:98514743 - 98514743(1)	intron_variant; upstream_gene_variant
rs3754881	chr2:98515630 - 98515630(1)	intron_variant; upstream_gene_variant
rs3754880	chr2:98515752 - 98515752(1)	intron_variant; upstream_gene_variant
rs17032866	chr2:98515952 - 98515952(1)	intron_variant; upstream_gene_variant
rs17032870	chr2:98516323 - 98516323(1)	intron_variant; upstream_gene_variant
rs3769716	chr2:98516842 - 98516842(1)	intron_variant; upstream_gene_variant
rs4851142	chr2:98517148 - 98517148(1)	intron_variant; upstream_gene_variant
rs17504774	chr2:98519164 - 98519164(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs2278214	chr2:98519275 - 98519275(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs2278213	chr2:98519596 - 98519596(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs2278212	chr2:98519803 - 98519803(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs961242	chr2:98522516 - 98522516(1)	downstream_gene_variant; intron_variant
rs3769701	chr2:98578648 - 98578648(1)	intron_variant; non_coding_transcript_variant
rs17033813	chr2:98580020 - 98580020(1)	intron_variant; non_coding_transcript_variant
rs3754877	chr2:98567556 - 98567556(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs3769708	chr2:98571187 - 98571187(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs2278206	chr2:98555781 - 98555781(1)	intron_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs3754878	chr2:98562921 - 98562921(1)	intron_variant; upstream_gene_variant
rs17505326	chr2:98540344 - 98540344(1)	intron_variant
rs17446058	chr2:98547697 - 98547697(1)	intron_variant
rs3769712	chr2:98536980 - 98536980(1)	intron_variant
rs2278208	chr2:98537766 - 98537766(1)	intron_variant
rs2278211	chr2:98533483 - 98533483(1)	intron_variant; synonymous_variant
rs3769714	chr2:98534339 - 98534339(1)	intron_variant
rs17033136	chr2:98532941 - 98532941(1)	intron_variant
rs17505088	chr2:98533010 - 98533010(1)	intron_variant
rs4599165	chr2:98528020 - 98528020(1)	intron_variant
rs3769715	chr2:98530392 - 98530392(1)	intron_variant
rs13402379	chr2:98592851 - 98592851(1)	3_prime_UTR_variant; downstream_gene_variant
rs2276603	chr2:98589499 - 98589499(1)	3_prime_UTR_variant; downstream_gene_variant
rs6736755	chr2:98587965 - 98587965(1)	3_prime_UTR_variant; downstream_gene_variant
rs3754875	chr2:98586284 - 98586284(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs2278210	chr2:98533735 - 98533735(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p16.1-q11.2	chr2:54700000-102100000	1 (1/0/0)
2q11	chr2:93900000-102100000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
17893707	563	Negative

Gene relationship with MDD

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Region: chr2:98444854..98594390 View in gBrowse