Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	IL10
Symbol Alias	CSIF, TGIF, IL10A, IL-10
Approved Name	interleukin 10
Name Alias	cytokine synthesis inhibitory factor, "T-cell growth inhibitory factor"
Location	1q31-q32
Position	chr1:206767602-206772494, -1
External Links	HGNC: 5962 Entrez Gene: 3586 Ensembl: ENSG00000136634 UCSC: uc001hen.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Clerici, M.,2009	Other variant: IL10_1082G/A	The distribution of cytokines interleukin (IL)-10 polymorphism was not significantly different in the groups.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 53)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006954	inflammatory response	biological process	IDA[10443688]	23
GO:0005125	cytokine activity	molecular function	NAS[10443688]	13

GO terms by database search (count: 51)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008083	growth factor activity	molecular function	NAS[1371884]	15
GO:0030183	B cell differentiation	biological process	NAS[8228801]	5
GO:0032800	receptor biosynthetic process	biological process	IDA[10443688]	2
GO:0050715	positive regulation of cytokine secretion	biological process	IDA[10443688]	3
GO:0002875	negative regulation of chronic inflammatory response to antigenic stimulus	biological process	IEA	1
GO:0060302	negative regulation of cytokine activity	biological process	IMP[9847016]	1
GO:0007267	cell-cell signaling	biological process	IC[1847510]	29
GO:0014823	response to activity	biological process	IEA	11
GO:0032695	negative regulation of interleukin-12 production	biological process	IEA	3
GO:0005615	extracellular space	cellular component	IDA[10443688]	85
GO:0071392	cellular response to estradiol stimulus	biological process	IEA	8
GO:0010468	regulation of gene expression	biological process	IDA[9184696]	6
GO:0071222	cellular response to lipopolysaccharide	biological process	NAS[14971032]	12
GO:0046427	positive regulation of JAK-STAT cascade	biological process	IBA	3
GO:0032715	negative regulation of interleukin-6 production	biological process	IDA[10443688]	4
GO:0030886	negative regulation of myeloid dendritic cell activation	biological process	IEA	1
GO:0042742	defense response to bacterium	biological process	IEA	4
GO:0042493	response to drug	biological process	IEA	57
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[7749983]	11
GO:0032689	negative regulation of interferon-gamma production	biological process	IEA	2
GO:0014854	response to inactivity	biological process	IEA	2
GO:0045348	positive regulation of MHC class II biosynthetic process	biological process	IEA	5
GO:0042092	type 2 immune response	biological process	TAS[11244051]	1
GO:0002904	positive regulation of B cell apoptotic process	biological process	IDA[9184696]	1
GO:0060670	branching involved in labyrinthine layer morphogenesis	biological process	IEA	3
GO:0045019	negative regulation of nitric oxide biosynthetic process	biological process	IEA	2
GO:0030889	negative regulation of B cell proliferation	biological process	IDA[9184696]	5
GO:0042100	B cell proliferation	biological process	NAS[8228801]	2
GO:0002740	negative regulation of cytokine secretion involved in immune response	biological process	IDA[10443688]	2
GO:2000352	negative regulation of endothelial cell apoptotic process	biological process	IMP[16034134]	2
GO:0051384	response to glucocorticoid	biological process	IDA[10443688]	11
GO:0042130	negative regulation of T cell proliferation	biological process	NAS[14971032]	6
GO:0005141	interleukin-10 receptor binding	molecular function	NAS[1847510]	1
GO:0045347	negative regulation of MHC class II biosynthetic process	biological process	TAS[11244051]	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	91
GO:0030595	leukocyte chemotaxis	biological process	TAS[9405662]	1
GO:0007568	aging	biological process	IEA	22
GO:0030097	hemopoiesis	biological process	TAS[11244051]	7
GO:0002237	response to molecule of bacterial origin	biological process	IDA[17449476]	1
GO:0044130	negative regulation of growth of symbiont in host	biological process	IEA	5
GO:0051930	regulation of sensory perception of pain	biological process	IEA	7
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	biological process	IEA	1
GO:0043066	negative regulation of apoptotic process	biological process	NAS[8312229]	46
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	biological process	IDA[18383040]	1
GO:0032868	response to insulin	biological process	IEA	10
GO:0007253	cytoplasmic sequestering of NF-kappaB	biological process	NAS[10975994]	1
GO:1903659	regulation of complement-dependent cytotoxicity	biological process	IMP[16034134]	1
GO:0045355	negative regulation of interferon-alpha biosynthetic process	biological process	NAS[9637497]	1
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[7749983]	58
GO:0034465	response to carbon monoxide	biological process	IEA	2
GO:0045191	regulation of isotype switching	biological process	NAS[8228801]	1

Gene related KEGG pathways (count: 7)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 7)

ID	Name	No. of Genes in BDgene
hsa05310	Asthma	2
hsa05320	Autoimmune thyroid disease	6
hsa05322	Systemic lupus erythematosus	4
hsa05330	Allograft rejection	6
hsa04060	Cytokine-cytokine receptor interaction	17
hsa04660	T cell receptor signaling pathway	13
hsa04630	Jak-STAT signaling pathway	14

Gene related BioCarta pathways (count: 5)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 5)

ID	Name	No. of Genes in BDgene
il10Pathway	IL-10 Anti-inflammatory Signaling Pathway	4
asbcellPathway	Antigen Dependent B Cell Activation	1
cytokinePathway	Cytokine Network	4
inflamPathway	Cytokines and Inflammatory Response	4
dcPathway	Dendritic cells in regulating TH1 and TH2 Development	3

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
IL10	IL10RA	NO	in vitro;in vivo	11485736 , 8248239 , 8897595 , 11717514 , 10231374 , 7759550
IL10	A2M	NO	in vitro	10714547
IL10	IL10RB	NO	in vitro;in vivo	11485736 , 9312047

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
IL10_1082G/A	point mutation		1 (0/1/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1q32.1	chr1:198700000-207100000	2 (1/0/1)
1q31-q32	chr1:185800000-214400000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Reference	ID in SZGene	Result Category
19153889	249	Positive
16378687	249	Positive
12667161	249	Negative
11922883	249	Positive
20393813	249	Positive
15374585	249	Positive
16905295	249	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 4)

Reference	Description	Category in MDD	Link in MK4MDD
19786281	We found no significant associations of the SNPs in IL10 family genes with either diagnostic group. Haplotype analysis revealed seven haplotype blocks, but their frequencies did not differ between patients and controls	Neg	IL10
20479761	Gene set analysis suggested up-regulation of a variety of pro- and anti-inflammatory cytokines, including interleukin 1alpha (IL-1alpha), IL-2, IL-3, IL-5, IL-8, IL-9, IL-10, IL-12A, IL-13, IL-15, IL-18, interferon gamma (IFNgamma), and lymphotoxin alpha (TNF superfamily member 1).	Pos	IL10
11952921	There were no significant differences in genotype frequencies of IL-10T/T, IL-10T/C, and IL-10C/C as well as allelic frequencies of IL-10T and IL-10*C between patients with major depression and controls in the Korean population.	Neg	IL10
20471034	We also found a state-independent marker, IL10	Pos	IL10

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Region: chr1:206767602..206772494 View in gBrowse