Gene Report

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Basic Info

Approved Symbol	GSTM1
Previous Symbol	GST1
Symbol Alias	MU, H-B
Approved Name	glutathione S-transferase mu 1
Previous Name	glutathione S-transferase M1
Location	1p13.3
Position	chr1:109687814-109709039, 1
External Links	HGNC: 4632 Entrez Gene: 2944 Ensembl: ENSG00000134184 UCSC: uc001dyk.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Mohammadynejad, P.,2011	Haplotype: (GSTM1_positive/null) - (GSTT1_positive/null)((GSTM1_null)-(GSTT1_null)), (GSTM1_positive/null) - (GSTT1_positive/null)((GSTM1_null)-(GSTT1_positive)), (GSTM1_positive/null) - (GSTT1_positive/null)((GSTM1_positive)-(GSTT1_null)) Other variant: GSTM1_positive/null	The present finding indicated that GSTM1 and GSTT1 are candidate polymorphisms for susceptibility to BDP among adolescents.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006749	glutathione metabolic process	biological process	IDA[8373352]	5
GO:0004364	glutathione transferase activity	molecular function	IDA[8373352]	3

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA[8373352]	322
GO:0043295	glutathione binding	molecular function	IDA[8373352]	2
GO:0018916	nitrobenzene metabolic process	biological process	IDA[8373352]	1
GO:0070458	cellular detoxification of nitrogen compound	biological process	IDA[8373352]	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0042803	protein homodimerization activity	molecular function	IPI[8373352]	71
GO:0042178	xenobiotic catabolic process	biological process	IDA[8373352]	1
GO:1901687	glutathione derivative biosynthetic process	biological process	TAS	6
GO:0006805	xenobiotic metabolic process	biological process	TAS	19
GO:0019899	enzyme binding	molecular function	IPI[8373352]	34
GO:0044281	small molecule metabolic process	biological process	TAS	117

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00982	Drug metabolism - cytochrome P450	6
hsa00980	Metabolism of xenobiotics by cytochrome P450	3

ID	Name	No. of Genes in BDgene	Brief Description
hsa00480	Glutathione metabolism	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GSTM1	GSTM2	NO	in vitro	6500576 , 12192076
GSTM1	MAP3K5	NO	in vitro;in vivo	11278289 , 12077134

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
GSTM1_positive/null	insertion/deletion		1 (1/0/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:109687814..109709039 View in gBrowse