Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	CPB2
Symbol Alias	CPU, PCPB, TAFI
Approved Name	carboxypeptidase B2 (plasma)
Previous Name	carboxypeptidase B2 (plasma, carboxypeptidase U)
Name Alias	thrombin-activatable fibrinolysis inhibitor, "carboxypeptidase U", "plasma carboxypeptidase B", "carboxypeptidase R"
Location	13q14.11
Position	chr13:46053186-46105076, -1
External Links	HGNC: 2300 Entrez Gene: 1361 Ensembl: ENSG00000080618 UCSC: uc001vaw.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00034, Product of P truncation <=0.01=0.02652, Product of P truncation <=0.001=0.00309. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0097421	liver regeneration	biological process	IEA	1
GO:0007596	blood coagulation	biological process	IEA	44
GO:0071333	cellular response to glucose stimulus	biological process	IEA	7
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23533145]	176
GO:0042730	fibrinolysis	biological process	IEA	1
GO:0010757	negative regulation of plasminogen activation	biological process	IEA	1
GO:2000346	negative regulation of hepatocyte proliferation	biological process	IEA	2
GO:0042493	response to drug	biological process	IEA	57
GO:0003331	positive regulation of extracellular matrix constituent secretion	biological process	IEA	2
GO:0009408	response to heat	biological process	IEA	12
GO:0005615	extracellular space	cellular component	IEA	85
GO:0004181	metallocarboxypeptidase activity	molecular function	IEA	1
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0006508	proteolysis	biological process	IEA	34
GO:0051918	negative regulation of fibrinolysis	biological process	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04610	Complement and coagulation cascades	3

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
fibrinolysisPathway	Fibrinolysis Pathway	1

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CPB2	F2	NO	in vitro	10777524
CPB2	PLG	NO	in vitro	1939207
CPB2	PZP	NO	in vitro	8662763

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q12-14	chr13:18900000-54700000	1 (0/1/0)
13q14	chr13:39500000-54700000	3 (0/1/2)
13q13-q14	chr13:31600000-54700000	1 (1/0/0)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

View in gBrowse

Region: chr13:46053186..46105076 View in gBrowse