Gene Report

Basic Info
Approved Symbol HSPA1A
Previous Symbol HSPA1
Symbol Alias HSP70-1
Approved Name heat shock 70kDa protein 1A
Previous Name heat shock 70kD protein 1A
Location 6p21.3
Position chr6:31815464-31817946, 1
External Links HGNC: 5232
Entrez Gene: 3303
Ensembl: ENSG00000204389
UCSC: uc003nxj.3
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Pae, C. U.,2010 A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. Positive Comment on Study
Pae, C. U.,2009 This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 58)

GO terms by PBA (count: 1)

GO terms by database search (count: 57)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 3)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 3)

Gene related interactors from protein-protein interactions data in HPRD (count: 55)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 4)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr6:31815464..31817946 View in gBrowse
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