Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	HSPA1A
Previous Symbol	HSPA1
Symbol Alias	HSP70-1
Approved Name	heat shock 70kDa protein 1A
Previous Name	heat shock 70kD protein 1A
Location	6p21.3
Position	chr6:31815464-31817946, 1
External Links	HGNC: 5232 Entrez Gene: 3303 Ensembl: ENSG00000204389 UCSC: uc003nxj.3
No. of Studies	2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Pae, C. U.,2010		A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders.	Positive	Comment on Study
Pae, C. U.,2009		This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 58)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[10205060]	283

GO terms by database search (count: 57)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008180	COP9 signalosome	cellular component	IDA[18850735]	4
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19199708]	176
GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	biological process	IDA[20625543]	5
GO:0044183	protein binding involved in protein folding	molecular function	IDA[15603737]	1
GO:0005829	cytosol	cellular component	IDA[21231916]; TAS	223
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[12150907]	25
GO:0031439	positive regulation of mRNA cleavage	biological process	IDA[20625543]	1
GO:0055131	C3HC4-type RING finger domain binding	molecular function	IPI[25281747]	1
GO:0016887	ATPase activity	molecular function	IDA[23921388]	13
GO:0042623	ATPase activity, coupled	molecular function	IDA[21231916]	1
GO:0070370	cellular heat acclimation	biological process	IMP[21231916]	1
GO:0072562	blood microparticle	cellular component	IDA[22516433]	8
GO:0003725	double-stranded RNA binding	molecular function	IDA[21266579]	9
GO:0043066	negative regulation of apoptotic process	biological process	IMP[17167422]; TAS[16130169]	46
GO:0001618	virus receptor activity	molecular function	IEA	3
GO:0016607	nuclear speck	cellular component	IDA[9553041]	16
GO:0046718	viral entry into host cell	biological process	IEA	3
GO:0034605	cellular response to heat	biological process	IDA[24061851]; TAS	11
GO:0016234	inclusion body	cellular component	IDA[15603737]	2
GO:0031072	heat shock protein binding	molecular function	IPI[21231916]	6
GO:0042026	protein refolding	biological process	IDA[15603737]	2
GO:0030308	negative regulation of cell growth	biological process	IMP[9553041]	11
GO:0006402	mRNA catabolic process	biological process	IDA[10205060]	2
GO:0090084	negative regulation of inclusion body assembly	biological process	IDA[15603737]	2
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[10205060]	50
GO:0031397	negative regulation of protein ubiquitination	biological process	IDA[12150907]	6
GO:0060548	negative regulation of cell death	biological process	IDA[12150907]; IMP[21231916]	5
GO:0006986	response to unfolded protein	biological process	IDA[10859165]	2
GO:0005783	endoplasmic reticulum	cellular component	TAS[16130169]	49
GO:0045648	positive regulation of erythrocyte differentiation	biological process	IMP[17167422]	2
GO:0050821	protein stabilization	biological process	TAS[24252804]	12
GO:0051082	unfolded protein binding	molecular function	IDA[21231916]; NAS[12150907]; TAS[16130169]	6
GO:0000151	ubiquitin ligase complex	cellular component	IDA[12150907]	4
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0034599	cellular response to oxidative stress	biological process	TAS[24252804]	7
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	biological process	IDA[20625543]	2
GO:0031982	vesicle	cellular component	IDA[19190083]	20
GO:0005515	protein binding	molecular function	IPI[12853476]	563
GO:0005524	ATP binding	molecular function	IDA[23921388]	118
GO:1902380	positive regulation of endoribonuclease activity	biological process	IDA[20625543]	1
GO:0030529	ribonucleoprotein complex	cellular component	IDA[17289661]	4
GO:0001664	G-protein coupled receptor binding	molecular function	IPI[12150907]	9
GO:0005739	mitochondrion	cellular component	TAS[16130169]	75
GO:0047485	protein N-terminus binding	molecular function	IPI[9553041]	12
GO:0005814	centriole	cellular component	IDA[24061851]	6
GO:0010467	gene expression	biological process	TAS	41
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0010941	regulation of cell death	biological process	IMP[21231916]	1
GO:1903896	positive regulation of IRE1-mediated unfolded protein response	biological process	IDA[20625543]	2
GO:0005737	cytoplasm	cellular component	IDA[10859165]; TAS[16130169]	322
GO:0019899	enzyme binding	molecular function	IPI[23921388]	34
GO:0016235	aggresome	cellular component	IDA[15885686]	3
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	biological process	IMP[17167422]	8
GO:0010628	positive regulation of gene expression	biological process	IMP[25281747]	23
GO:1900034	regulation of cellular response to heat	biological process	TAS	10
GO:0008285	negative regulation of cell proliferation	biological process	IMP[9553041]	41

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04010	MAPK signaling pathway	39

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04612	Antigen processing and presentation	7

Gene related BioCarta pathways (count: 3)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	12
tidPathway	Chaperones modulate interferon Signaling Pathway	3
p53hypoxiaPathway	Hypoxia and p53 in the Cardiovascular system	6

Gene related interactors from protein-protein interactions data in HPRD (count: 55)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HSPA1A	FANCC	NO	in vitro;in vivo	11500375 , 12397061
HSPA1A	DNAJA3	YES	in vivo	11679576 , 14993262
HSPA1A	DNAJB1	NO	in vitro;in vivo	10593983
HSPA1A	NQO1	YES	in vitro	11821413
HSPA1A	PTGES3	NO	in vivo	12077419
HSPA1A	WDR16	NO	in vivo	15967112
HSPA1A	TP53	NO	in vivo	7811761
HSPA1A	HCFC1	NO	in vitro	12670868
HSPA1A	BRSK1	NO	in vitro;in vivo	16306228
HSPA1A	DYX1C1	NO	in vivo	15189447
HSPA1A	TCERG1	NO	in vitro	15456888
HSPA1A	SOX9	NO	in vitro;in vivo	11356186
HSPA1A	HSPBP1	NO	in vitro;yeast 2-hybrid	9830037
HSPA1A	ST13	YES	in vivo	8887650
HSPA1A	YWHAZ	NO	in vivo	15324660
HSPA1A	YWHAQ	YES	in vivo	15324660
HSPA1A	MOS	NO	in vitro;in vivo	10376524
HSPA1A	YWHAG	NO	in vivo	15324660
HSPA1A	TSSK6	YES	in vivo	15870294
HSPA1A	EIF2AK2	NO	in vivo	12397061
HSPA1A	DNAJA2	NO	in vitro	10651811
HSPA1A	MSR1	NO	in vitro;in vivo	11785981
HSPA1A	APEX1	NO	in vitro;in vivo	11133992 , 10629618
HSPA1A	TTC1	NO	in vitro	14503850
HSPA1A	SLC5A1	YES	in vitro	12082088
HSPA1A	KRT7	NO	in vivo	11888936
HSPA1A	MAP3K5	NO	in vitro;in vivo	12391142
HSPA1A	TOMM70A	NO	in vivo	12526792
HSPA1A	RHOA	NO	in vivo	12490434
HSPA1A	RAP1A	NO	in vivo	15207703
HSPA1A	YWHAB	NO	in vivo	15324660
HSPA1A	BAG3	NO	in vitro;in vivo	9873016 , 10980614
HSPA1A	HSBP1	NO	in vitro;in vivo	9649501
HSPA1A	BAG2	NO	in vitro;in vivo;yeast 2-hybrid	9873016
HSPA1A	IKBKG	NO	in vivo	11877453
HSPA1A	GRIN1	YES	in vivo	10862698
HSPA1A	DNAJC3	NO	in vivo;yeast 2-hybrid	9920933
HSPA1A	TRIAP1	NO	in vitro;in vivo	15735003
HSPA1A	PTMA	NO	in vitro	11310559
HSPA1A	PEX5	NO	in vitro	11415446
HSPA1A	AIFM1	NO	in vitro;in vivo	11533664 , 12930708
HSPA1A	APAF1	NO	in vivo	10934467
HSPA1A	CDK9	NO	in vitro;in vivo	10617616
HSPA1A	SNRK	NO	in vitro;in vivo	16306228
HSPA1A	PPP1R15A	NO	in vivo	12724406
HSPA1A	STUB1	NO	in vitro;in vivo;yeast 2-hybrid	10330192 , 15189447
HSPA1A	DNAJB11	NO	in vitro	11584023
HSPA1A	HSF1	NO	in vitro	1628823 , 9699716
HSPA1A	HSPA8	NO	in vitro	9305631 , 11741305
HSPA1A	BAG1	NO	in vitro;in vivo	11101523 , 9305631 , 11741305
HSPA1A	GRIN2D	YES	in vivo	10862698
HSPA1A	BAG4	NO	in vitro;in vivo	11527400 , 11909948
HSPA1A	STIP1	NO	in vitro;in vivo	12161444 , 10786835
HSPA1A	KRT18	NO	in vitro	7529764
HSPA1A	PRKCA	NO	in vitro;in vivo	12080070

Related other genetic factors

Gene related SNPs (count: 4)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2227956	chrCHR_HSCHR6_MHC_QBL_CTG1:31800731 - 31800731(1)	missense_variant; upstream_gene_variant	1(0/1/0)
rs562047	chrCHR_HSCHR6_MHC_QBL_CTG1:31806321 - 31806321(1)	intron_variant; missense_variant; upstream_gene_variant	1(1/0/0)
rs1043618	chrCHR_HSCHR6_MHC_QBL_CTG1:31805965 - 31805965(1)	5_prime_UTR_variant; upstream_gene_variant	1(0/1/0)
rs2075799	chrCHR_HSCHR6_MHC_QBL_CTG1:31800988 - 31800988(1)	synonymous_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p21	chr6:30500000-46200000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
15963589	373	Negative
18299791	373	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
19582769	A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders.	Positive

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr6:31815464..31817946 View in gBrowse