BDgene

Gene Report

Basic Info
Approved Symbol TPP2
Approved Name tripeptidyl peptidase II
Location 13q32-q33
Position chr13:102597003-102679958, 1
External Links HGNC: 12016
Entrez Gene: 7174
Ensembl: ENSG00000134900
UCSC: uc001vpi.4
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 6 SNP typed, Median D'=1, Median r<sup>2</sup> =0.25, 1 LD blocks, 0.73 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. Negative Comment on Study
Johnson, C.,2009 Monte-Carlo Simulation P-value = 0.0179. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 12)

GO terms by PBA (count: 1)

GO terms by database search (count: 11)


Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)


Gene relationship with MDD

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Region: chr13:102597003..102679958 View in gBrowse
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