Gene Report

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Basic Info

Approved Symbol	TPP2
Approved Name	tripeptidyl peptidase II
Location	13q32-q33
Position	chr13:102597003-102679958, 1
External Links	HGNC: 12016 Entrez Gene: 7174 Ensembl: ENSG00000134900 UCSC: uc001vpi.4
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		6 SNP typed, Median D'=1, Median r<sup>2</sup> =0.25, 1 LD blocks, 0.73 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0179. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0004177	aminopeptidase activity	molecular function	IEA	3
GO:0004175	endopeptidase activity	molecular function	TAS[9974389]	8
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005829	cytosol	cellular component	TAS	223
GO:0000209	protein polyubiquitination	biological process	TAS	7
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	7
GO:0008240	tripeptidyl-peptidase activity	molecular function	TAS[9974389]	3
GO:0006508	proteolysis	biological process	IBA	34
GO:0004252	serine-type endopeptidase activity	molecular function	IBA	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q33.1-q33.3	chr13:101100000-109600000	1 (0/1/0)
13q21-33	chr13:54700000-109600000	1 (0/0/1)
13q31-q34	chr13:78500000-114364328	1 (0/0/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend

Reference	ID in SZGene	Result Category
16380905	299	Trend

Gene relationship with MDD

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Region: chr13:102597003..102679958 View in gBrowse