Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	NTS
Approved Name	neurotensin
Name Alias	neuromedin N, "pro-neurotensin/neuromedin"
Location	12q21.31
Position	chr12:85874295-85882992, 1
External Links	HGNC: 8038 Entrez Gene: 4922 Ensembl: ENSG00000133636 UCSC: uc001tag.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Austin, J.,2000	Haplotype: (NTS_3A>G) - (NTS_166C>G)() Other variant: NTS_166C>G, NTS_3A>G	No evidence for association was found, and our data therefore suggest that sequence variation in this gene does not make an important contribution to susceptibility to bipolar disorder.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[23597562]	563
GO:0005184	neuropeptide hormone activity	molecular function	IEA	8
GO:0005576	extracellular region	cellular component	TAS	97
GO:0030133	transport vesicle	cellular component	IEA	4
GO:0050880	regulation of blood vessel size	biological process	IEA	5
GO:0007165	signal transduction	biological process	NAS[8954810]	136

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NTS	NTSR2	YES	in vitro;in vivo	11801734 , 16087676
NTS	MEP1A	NO	in vitro	11278902
NTS	NLN	NO	in vitro	8869556 , 12609826 , 7836437
NTS	ACE2	NO	in vitro	11815627
NTS	NTSR1	NO	in vitro;in vivo	11559354 , 16087676
NTS	CPE	NO	in vivo	8770919
NTS	SORT1	NO	in vitro;in vivo	9756851 , 16087676

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
NTS_166C>G	point mutation		1 (0/1/0)
NTS_3A>G	point mutation		1 (1/0/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q	chr12:38200000-133851895	1 (1/0/0)
12q21	chr12:71100000-92200000	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
10822351	140	Negative

Gene relationship with MDD

View in gBrowse

Region: chr12:85874295..85882992 View in gBrowse