Gene Report

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Basic Info

Approved Symbol	DBP
Symbol Alias	DABP
Approved Name	D site of albumin promoter (albumin D-box) binding protein
Location	19q13.33
Position	chr19:48630030-48637438, -1
External Links	HGNC: 2697 Entrez Gene: 1628 Ensembl: ENSG00000105516 UCSC: uc002pjx.4
No. of Studies	3 (Positive: 0; Negative: 3; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 3)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Soria, V.,2010	SNP: rs386551	No significant associations of DBP gene were found in BPD patients.	Negative	Comment on Study
Mansour, H. A.,2009		Gene-based tests:X<sup>2</sup>=2.109, P-value = 0.273 in recessive model, X<sup>2</sup>=1.578, P-value = 0.377 in dominant model, X<sup>2</sup>=0.703, P-value = 0.632 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI.	Negative	Comment on Study
Nievergelt, C. M., 2006		Single SNP TDT analyses showed no evidence for association to BPAD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001889	liver development	biological process	IEA	14
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0007623	circadian rhythm	biological process	TAS	40
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IDA[20093779]	18
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular function	IDA[20093779]	10
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[20093779]	91
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[8786133]	21

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DBP	HLF	NO	in vitro;in vivo	10073576
DBP	TEF	NO	in vitro	12805554
DBP	CEBPA	NO	in vivo	8499951
DBP	EP300	NO	in vitro;in vivo	10364202

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs386551	chr19:48635029 - 48635029(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs550455		chr19:48633258 - 48633258(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
19p13-q13	chr19:0-58617616	1 (0/1/0)
Chr 19	chr19:0-58617616	2 (0/2/0)
19q13	chr19:31900000-58617616	2 (0/2/0)
19q13.33-qter	chr19:47500000-58617616	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19839995	Gene-based tests:X<sup>2</sup>=2.864, P-value = 0.173 in dominant model in SZ/SZA, X<sup>2</sup>=2.134, P-value = 0.251 in recessive model in SZ/SZA, X<sup>2</sup>=1.57, P-value = 0.371 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
19839995	925	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20072116	Significant associations of DBP gene were found in MDD patients.	Positive

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Region: chr19:48630030..48637438 View in gBrowse