Reference |
Tested Markers |
Statistical Values/Author Comments |
Result Category |
Comment on Study |
Chen, C., 2008 |
|
The pooled OR for the AA genotype relative to the CC genotype was significant (z = 2.18, p = 0.029), with a value of 1.41 and a 95% CI of 1.04-1.93. The AA genotype was also a significant risk factor (z = 2.72, p = 0.006) in relation to the AC genotype, with a pooled OR of 1.37 and a 95% CI of 1.09-1.72. The AC and CC genotypes had approximately equal nonsignificant effects (z = 0.16, p = 0.870) on risk for BPD (OR = 1.02, 95% CI: 0.83-1.25)..
This pattern of results suggested that the A allele may increase risk for BPD in a recessive manner. |
Positive
|
Comment on Study |
Rietschel, M.,2000 |
Other variant: TPH1_A218C |
Our results, therefore, do not support the hypothesis that the TPH gene is involved in the etiology of bipolar disorder. |
Negative
|
Comment on Study |
Serretti, A.,2002 |
Other variant: TPH1_A218C |
Our study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in bipolar disorder. |
Negative
|
Comment on Study |
Chen, D.,2011 |
SNP: rs1800532 |
The TPH1 A218C polymorphism is a potential biomarker for bipolar disorder and alcohol dependence risk in Caucasian population. |
Positive
|
Comment on Study |
Lai, T. J.,2005 |
SNP: rs1800532, rs2108977, rs211105, rs2237907, rs623580, rs684302 Haplotype: (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(G-G-G-A-G-A-C-C-C-A), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(G-G-T-A-G-A-C-C-C-A), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(G-G-T-T-G-C-C-C-T-A), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(G-G-T-T-G-C-C-C-T-G), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(T-A-G-A-G-A-C-A-T-G), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(T-A-G-A-G-A-C-C-T-G), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(T-A-G-T-A-A-C-A-C-A), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(T-A-G-T-A-A-C-C-T-G), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(T-A-G-T-A-A-G-A-C-A), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(T-A-G-T-A-A-G-A-T-A), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(T-A-G-T-G-A-C-C-T-G), (TPH1_5'flanking_T-1721G) - (TPH1_5'flanking_A-1067G) - (TPH1_5'flanking_G-347T) - (TPH1_Intron1_T3804A) - (TPH1_Intron2_G7465A) - (TPH1_Intron3_A12517C) - (TPH1_Intron6_C18626G) - (TPH1_Intron7_A20004C) - (TPH1_3'UTR_C27224T) - (TPH1_3'UTR_A27237G)(T-A-G-T-G-C-G-A-C-A) Other variant: TPH1_3'UTR_A27237G, TPH1_5'flanking_A-1067G, TPH1_5'flanking_G-347T, TPH1_5'flanking_T-1721G |
Results of this study did not support the role of TPH1 gene in BPD etiology. |
Negative
|
Comment on Study |
Choi, K. Y., 2010 |
Other variant: TPH1_promoter_218A/C |
There was no association of variant in this gene with bipolar disorder. |
Negative
|
Comment on Study |
Bellivier, F., 1998 (a) |
Other variant: TPH1_A218C |
This result suggests the involvement of the TPH gene in susceptibility to manic-depressive illness. This preliminary result requires confirmation in further groups of patients and controls. |
Positive
|
Comment on Study |
Lin, Y. M., 2007 |
Haplotype: TPH1_-346G - rs4570625 - rs11178997 - rs11178998(G, T-A-G), TPH1_-346T - rs4570625 - rs11178997 - rs11178998(T, T-A-G), TPH1_G-346T - rs4570625 - rs11178997 - rs11178998(G/T, T-A-G), TPH1_G-346T - rs4570625 - rs11178997 - rs11178998(G/T, non T-A-G) |
The effect of TPH2 on BPD etiology can be influenced by the presence of TPH1. |
Positive
|
Comment on Study |
Vincent, J. B.,1999(a) |
Other variant: TPH1_BfaI Polymorphism |
No significant differences were found in bipolar groups. |
Negative
|
Comment on Study |
McQuillin, A.,1999 |
Other variant: TPH1_intron 7_218A/C |
We found no association between TPH variant and bipolar disorder in our caucasian populations. |
Negative
|
Comment on Study |
Kunugi, H.,1999(a) |
Other variant: TPH1_intron 7_218A/C |
The authors conclude that the examined polymorphisms are unlikely to have major relevance to the pathogenesis of affective disorders or suicidal behavior. |
Negative
|
Comment on Study |
Serretti, A.,2001(a) |
Other variant: TPH1_A218C |
TPH variants were not associated with major psychoses, but a trend was observed toward an excess of TPH*A/A in bipolar disorder. |
Positive
|
Comment on Study |
Souery, D.,2001 |
Other variant: TPH1_A218C |
We failed to detect an association between the A218C polymorphism of the TPH gene and BPAD and UPAD in a large European sample. |
Negative
|
Comment on Study |
Rotondo, A.,2002 |
Other variant: TPH1_A218C |
TPH A218C variants are not, therefore, a major liability factor for the symptoms of major psychoses to have in the present sample. |
Negative
|
Comment on Study |