Gene Report

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Basic Info

Approved Symbol	DHX15
Previous Symbol	DDX15
Symbol Alias	HRH2, DBP1, PRP43, PrPp43p, PRPF43
Approved Name	DEAH (Asp-Glu-Ala-His) box helicase 15
Previous Name	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15, "DEAH (Asp-Glu-Ala-His) box polypeptide 15"
Location	4p15.3
Position	chr4:24517441-24584550, -1
External Links	HGNC: 2738 Entrez Gene: 1665 Ensembl: ENSG00000109606 UCSC: uc003gqx.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Byrne, E. M., 2014		P-value=0.04. The evidence for a role for common risk variants in circadian genes is slightly stronger for BPD, with two genesâ€”BHLHB3 and DBP1â€”showing nominal significance for the gene-based test and nine genes harboring a SNP with a P-value <0.01	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000398	mRNA splicing, via spliceosome	biological process	IBA	6
GO:0005634	nucleus	cellular component	IDA	283
GO:0008380	RNA splicing	biological process	IC[15146077]	8

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003725	double-stranded RNA binding	molecular function	IDA[21266579]	9
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0005524	ATP binding	molecular function	IEA	118
GO:0071008	U2-type post-mRNA release spliceosomal complex	cellular component	IDA[19103666]	2
GO:0006397	mRNA processing	biological process	TAS[7935475]	8
GO:0004004	ATP-dependent RNA helicase activity	molecular function	IBA	4
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005515	protein binding	molecular function	IPI[17332742]	563
GO:0005730	nucleolus	cellular component	IEA	28
GO:0003724	RNA helicase activity	molecular function	TAS[7935475]	1
GO:0005737	cytoplasm	cellular component	IBA	322
GO:0005689	U12-type spliceosomal complex	cellular component	IDA[15146077]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DHX15	YWHAG	NO	in vivo	15324660
DHX15	YWHAB	NO	in vivo	15324660

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p14-p15	chr4:11300000-41200000	1 (0/1/0)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
24687905	P-value=0.13. The results from the gene-based test indicate that DBP1 is the best candidates among the circadian genes to influence SCZ risk.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
24687905	P-value=0.58. Gene-based tests show no significant association between this gene and MDD.	Negative

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Region: chr4:24517441..24584550 View in gBrowse