Gene Report

Basic Info
Approved Symbol IFNG
Approved Name interferon, gamma
Location 12q14
Position chr12:68154768-68159747, -1
External Links HGNC: 5438
Entrez Gene: 3458
Ensembl: ENSG00000111537
UCSC: uc001stw.1
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yoon, H. K.,2012 SNP: rs2430561 Our results suggest that the IFNG+874A/T polymorphism may have important effects related to susceptibility to BD and that the T allele may be associated with an increased risk of developing BD. Positive Comment on Study
Clerici, M.,2009 Other variant: IFNG_874T/A Our data reported a different genotype and allele distribution of -308 TNF-α and +874 IFN-γ in the bipolar II group that showed a higher percentage of subjects characterized by a lower production of both cytokines. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 69)

GO terms by PBA (count: 2)

GO terms by database search (count: 67)

Gene related KEGG pathways (count: 10)

Gene related BioCarta pathways (count: 13)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr12:68154768..68159747 View in gBrowse
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