Gene Report

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Basic Info

Approved Symbol	ZBTB20
Previous Symbol	ZNF288
Symbol Alias	ODA-8S, DKFZp566F123, DPZF
Approved Name	zinc finger and BTB domain containing 20
Previous Name	zinc finger protein 288
Location	3q13.2
Position	chr3:114314501-115147271, -1
External Links	HGNC: 13503 Entrez Gene: 26137 Ensembl: ENSG00000181722 UCSC: uc003ebi.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs1274270	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283
GO:0003677	DNA binding	molecular function	IEA	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	62
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	IEA	14
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0006351	transcription, DNA-templated	biological process	IEA	103

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1274270	chr3:114610562 - 114610562(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q13.3	chr3:113500000-121900000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
19850283	901	Negative

Gene relationship with MDD

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Region: chr3:114314501..115147271 View in gBrowse