Gene Report

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Basic Info

Approved Symbol	INPP1
Approved Name	inositol polyphosphate-1-phosphatase
Location	2q32
Position	chr2:190343470-190371665, 1
External Links	HGNC: 6071 Entrez Gene: 3628 Ensembl: ENSG00000151689 UCSC: uc010fsb.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Piccardi, M. P.,2002	Other variant: INPP1_C973A	In our trios sample, the transmission disequilibrium test revealed no preferential transmission of alleles of the INPP1 from heterozygous parents to probands.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0052829	inositol-1,3,4-trisphosphate 1-phosphatase activity	molecular function	TAS	1
GO:0016311	dephosphorylation	biological process	IEA; TAS[8390685]	14
GO:0046854	phosphatidylinositol phosphorylation	biological process	IEA	10
GO:0005829	cytosol	cellular component	TAS	223
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0006796	phosphate-containing compound metabolic process	biological process	TAS[8390685]	6
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	molecular function	TAS	1
GO:0007165	signal transduction	biological process	TAS[8390685]	136
GO:0043647	inositol phosphate metabolic process	biological process	TAS	7

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00562	Inositol phosphate metabolism	11
hsa04070	Phosphatidylinositol signaling system	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
INPP1	LIG1	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
INPP1_C973A	point mutation		1 (0/1/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q24-33	chr2:154000000-208200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
17893707	562	Negative

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
24391664	GPLS genes significantly dysregulated in anterior cingulate cortex by microarray	Pos	INPP1

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Region: chr2:190343470..190371665 View in gBrowse