Gene Report

Basic Info
Approved Symbol PRODH
Symbol Alias HSPOX2, PRODH1, PIG6, PRODH2, TP53I6
Approved Name proline dehydrogenase (oxidase) 1
Previous Name proline dehydrogenase (proline oxidase )
Location 22q11.2
Position chr22:18912777-18936553, -1
External Links HGNC: 9453
Entrez Gene: 5625
Ensembl: ENSG00000100033
UCSC: uc002zok.4
No. of Studies 4 (Positive: 0; Negative: 4; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Abou Jamra, R.,2005(a) Haplotype: PRODH1945 - PRODH1482(), PRODH2026 - PRODH1945(), PRODH2026 - PRODH1945 - PRODH1482()
Other variant: PRODH-1482, PRODH-1945, PRODH-2026
In conclusion, our results do not support a significant role of common variation at the PRODH locus contributing to the development of schizophrenia or BPAD. Negative Comment on Study
Fallin, M. D.,2005 6 SNP typed, Median D'=0.66, Median r<sup>2</sup> =0.03, 4 LD blocks, 0.07 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. Negative Comment on Study
Jacquet, H.,2005 Other variant: PRODH_exon12_A472T, PRODH_exon12_R431H We found no association between common PRODH polymorphisms and any of the psychotic disorders. Negative Comment on Study
Prata, D. P., 2006 SNP: rs1808320, rs372055, rs383964, rs385440, rs450046 Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipolar affective disorder 1 in the Scottish population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 12)

GO terms by PBA (count: 0)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 14)

Literature-origin SNPs (count: 5)

LD-proxies (count: 9)

Gene related CNVs (count: 0)

Gene related other variants (count: 5)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 10)

Gene relationship with MDD

View in gBrowse

Region: chr22:18912777..18936553 View in gBrowse
View in gBrowse