Gene Report

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Basic Info

Approved Symbol	FBXO38
Symbol Alias	MOKA, SP329, FLJ13962, Fbx38
Approved Name	F-box protein 38
Location	5q33.1
Position	chr5:148383935-148442836, 1
External Links	HGNC: 28844 Entrez Gene: 81545 Ensembl: ENSG00000145868 UCSC: uc003lpg.2
No. of Studies	2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Feng, T.,2010	SNP: rs6861078	This gene showed moderate association evidence.	Trend	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.00032, Product of P truncation <=0.01=0.00032, Product of P truncation <=0.001=0.00052. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IEA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FBXO38	KLF7	NO	in vitro;in vivo;yeast 2-hybrid	14729953

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6861078	chr5:148433338 - 148433338(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q31-q33	chr5:131200000-160500000	1 (1/0/0)
5q32	chr5:145100000-150400000	2 (0/2/0)
5q32-5q33.3	chr5:145100000-160500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00456, Product of P truncation <=0.01=0.0053, Product of P truncation <=0.001=NA It showed evidence for association with SZ.	Positive

Gene relationship with MDD

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Region: chr5:148383935..148442836 View in gBrowse