Gene Report

Basic Info
Approved Symbol SOD2
Approved Name superoxide dismutase 2, mitochondrial
Location 6q25
Position chr6:159669057-159762529, -1
External Links HGNC: 11180
Entrez Gene: 6648
Ensembl: ENSG00000112096
UCSC: uc003qsg.4
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Pae, C. U., 2006 Other variant: SOD2_Ala-9Val This preliminary data suggests that at least in the Korean population, the Ala-9Val MnSOD polymorphism is not associated with the development of mood disorders or their clinical parameters. However, more study with a larger population sample will be needed. Negative Comment on Study
Fullerton, J. M.,2010 SNP: rs4880, rs5746136
Haplotype: rs3792797 - rs8177435 - rs5746136 - rs4880(), rs3792797 - rs4880(), rs5746136 - rs4880(T-G)
We provide evidence that haplotypes within SOD2 are associated with increased risk for bipolar disorder and that an interaction at both the genotype and haplotype level between SOD2 and GPX3 further increases disease risk. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 64)

GO terms by PBA (count: 2)

GO terms by database search (count: 62)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr6:159669057..159762529 View in gBrowse
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