Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	KIF13A
Symbol Alias	bA500C11.2
Approved Name	kinesin family member 13A
Location	6p23
Position	chr6:17759183-17987623, -1
External Links	HGNC: 14566 Entrez Gene: 63971 Ensembl: ENSG00000137177 UCSC: uc003ncg.4
No. of Studies	2 (Positive: 0; Negative: 1; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		13 SNP typed, Median D'=0.97, Median r<sup>2</sup> =0.34, 2 LD blocks, 0.72 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in BP.. This gene is suggestive to BP , not suggestive to SZ/SZA.	Trend	Comment on Study
Yosifova, A.,2009	SNP: rs1044654, rs2296197, rs3734234, rs942376	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

GO terms by PBA (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005813	centrosome	cellular component	IDA[20208530]	34
GO:0005524	ATP binding	molecular function	IEA	118
GO:0006886	intracellular protein transport	biological process	IMP[20208530]	10
GO:0005874	microtubule	cellular component	IEA	24
GO:0005515	protein binding	molecular function	IPI[19841138]	563
GO:0007018	microtubule-based movement	biological process	IBA	7
GO:0016887	ATPase activity	molecular function	IBA	13
GO:0008017	microtubule binding	molecular function	IEA	10
GO:0008152	metabolic process	biological process	IBA; IEA; ISS	50
GO:0003777	microtubule motor activity	molecular function	IBA; ISS	8
GO:0005871	kinesin complex	cellular component	IBA	6
GO:0000139	Golgi membrane	cellular component	IEA	36
GO:0035459	cargo loading into vesicle	biological process	IMP[19841138]	1
GO:0072383	plus-end-directed vesicle transport along microtubule	biological process	ISS	2
GO:0008333	endosome to lysosome transport	biological process	IMP[19841138]	4
GO:0032588	trans-Golgi network membrane	cellular component	ISS	4
GO:0043001	Golgi to plasma membrane protein transport	biological process	ISS	6
GO:0032438	melanosome organization	biological process	IMP[19841138]	2
GO:0000910	cytokinesis	biological process	IMP[20208530]	5
GO:0030496	midbody	cellular component	IDA[20208530]	8
GO:0010008	endosome membrane	cellular component	IDA[19841138]	17

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
KIF13A	PPP1CA	NO	in vivo	19094064
KIF13A	GTF2H1	NO	in vitro;in vivo	10777215
KIF13A	ATF7IP	NO	yeast 2-hybrid	15231748
KIF13A	AP1B1	NO	in vitro;in vivo	11106728

Related other genetic factors

Gene related SNPs (count: 52)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs942376	chr6:17781219 - 17781219(1)	downstream_gene_variant; synonymous_variant	1(0/1/0)
rs2296197	chr6:17764524 - 17764524(1)	synonymous_variant	1(0/1/0)
rs1044654	chr6:17764048 - 17764048(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1(0/1/0)
rs3734234	chr6:17794263 - 17794263(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant	1(0/1/0)

LD-proxies (count: 48)

rs_ID	Location	Functional Annotation
rs7761748	chr6:17810985 - 17810985(1)	downstream_gene_variant; intron_variant
rs634252	chr6:17852368 - 17852368(1)	downstream_gene_variant; intron_variant
rs12664891	chr6:17834341 - 17834341(1)	intron_variant
rs3822906	chr6:17816783 - 17816783(1)	intron_variant; non_coding_transcript_variant
rs10949448	chr6:17815079 - 17815079(1)	intron_variant; non_coding_transcript_variant
rs9477548	chr6:17876229 - 17876229(1)	intron_variant; non_coding_transcript_variant
rs604139	chr6:17868076 - 17868076(1)	intron_variant; non_coding_transcript_variant
rs594115	chr6:17860176 - 17860176(1)	intron_variant; non_coding_transcript_variant
rs624105	chr6:17855633 - 17855633(1)	intron_variant; non_coding_transcript_variant
rs1014979	chr6:17895467 - 17895467(1)	intron_variant; non_coding_transcript_variant
rs6903673	chr6:17895225 - 17895225(1)	intron_variant; non_coding_transcript_variant
rs9371023	chr6:17893291 - 17893291(1)	intron_variant; non_coding_transcript_variant
rs724916	chr6:17885171 - 17885171(1)	intron_variant; non_coding_transcript_variant
rs2206144	chr6:17904908 - 17904908(1)	intron_variant; non_coding_transcript_variant
rs2067849	chr6:17906098 - 17906098(1)	intron_variant; non_coding_transcript_variant
rs9371024	chr6:17907504 - 17907504(1)	intron_variant; non_coding_transcript_variant
rs1983575	chr6:17910314 - 17910314(1)	intron_variant; non_coding_transcript_variant
rs1014536	chr6:17898684 - 17898684(1)	intron_variant; non_coding_transcript_variant
rs1014535	chr6:17899415 - 17899415(1)	intron_variant; non_coding_transcript_variant
rs1014534	chr6:17899465 - 17899465(1)	intron_variant; non_coding_transcript_variant
rs9477555	chr6:17903189 - 17903189(1)	intron_variant; non_coding_transcript_variant
rs7757011	chr6:17928258 - 17928258(1)	intron_variant; non_coding_transcript_variant
rs6459580	chr6:17934148 - 17934148(1)	intron_variant; non_coding_transcript_variant
rs7760740	chr6:17934284 - 17934284(1)	intron_variant; non_coding_transcript_variant
rs4712321	chr6:17935187 - 17935187(1)	intron_variant; non_coding_transcript_variant
rs9297052	chr6:17919332 - 17919332(1)	intron_variant; non_coding_transcript_variant
rs9396816	chr6:17919359 - 17919359(1)	intron_variant; non_coding_transcript_variant
rs6924302	chr6:17924611 - 17924611(1)	intron_variant; non_coding_transcript_variant
rs742282	chr6:17927782 - 17927782(1)	intron_variant; non_coding_transcript_variant
rs12524859	chr6:17770004 - 17770004(1)	downstream_gene_variant; intron_variant
rs10949464	chr6:17841420 - 17841420(1)	intron_variant
rs2328176	chr6:17974403 - 17974403(1)	intron_variant; non_coding_transcript_variant
rs12525646	chr6:17836763 - 17836763(1)	intron_variant
rs676296	chr6:17849911 - 17849911(1)	intron_variant
rs3734236	chr6:17816900 - 17816900(1)	intron_variant; non_coding_transcript_variant
rs12192810	chr6:17843722 - 17843722(1)	intron_variant
rs607690	chr6:17860897 - 17860897(1)	intron_variant; non_coding_transcript_variant
rs6459581	chr6:17938350 - 17938350(1)	intron_variant; non_coding_transcript_variant
rs665966	chr6:17856473 - 17856473(1)	intron_variant; non_coding_transcript_variant
rs6937334	chr6:17935773 - 17935773(1)	intron_variant; non_coding_transcript_variant
rs2744057	chr6:17973737 - 17973737(1)	intron_variant; non_coding_transcript_variant
rs2876466	chr6:17951725 - 17951725(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs733697	chr6:17808090 - 17808090(1)	downstream_gene_variant; intron_variant
rs4716184	chr6:17780554 - 17780554(1)	downstream_gene_variant; intron_variant
rs7749814	chr6:17821442 - 17821442(1)	intron_variant; upstream_gene_variant
rs6920106	chr6:17815485 - 17815485(1)	intron_variant; non_coding_transcript_variant
rs4716190	chr6:17833982 - 17833982(1)	synonymous_variant
rs7770400	chr6:17822893 - 17822893(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p22	chr6:15200000-30500000	1 (0/1/0)
6p22.3	chr6:15200000-25200000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
16380905	This gene is suggestive to BP , not suggestive to SZ/SZA.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
16380905	377	Negative

Gene relationship with MDD

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Region: chr6:17759183..17987623 View in gBrowse