Gene Report

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Basic Info

Approved Symbol	NAT1
Previous Symbol	AAC1
Approved Name	N-acetyltransferase 1 (arylamine N-acetyltransferase)
Location	8p22
Position	chr8:18170477-18223689, 1
External Links	HGNC: 7645 Entrez Gene: 9 Ensembl: ENSG00000171428 UCSC: uc003wys.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		2 SNP typed, Median D'=0.04, Median r<sup>2</sup> =0, 2 LD blocks, NA block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005829	cytosol	cellular component	TAS	223
GO:0004060	arylamine N-acetyltransferase activity	molecular function	IEA	2
GO:0006805	xenobiotic metabolic process	biological process	TAS	19
GO:0044281	small molecule metabolic process	biological process	TAS	117

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00983	Drug metabolism - other enzymes	2

ID	Name	No. of Genes in BDgene	Brief Description
hsa00232	Caffeine metabolism	1

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NAT1	NAA10	NO	in vitro;in vivo	12888564

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p22	chr8:12800000-19200000	1 (0/0/1)
8pter-p22	chr8:0-19200000	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
11436130	308	Negative
16380905	308	Negative

Gene relationship with MDD

View in gBrowse

Region: chr8:18170477..18223689 View in gBrowse