Gene Report

Basic Info
Approved Symbol TUBA8
Previous Symbol TUBAL2
Approved Name tubulin, alpha 8
Location 22q11
Position chr22:18110331-18146554, 1
External Links HGNC: 12410
Entrez Gene: 51807
Ensembl: ENSG00000183785
UCSC: uc002znv.2
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 2 SNP typed, Median D'=0.53, Median r<sup>2</sup> =0.03, 2 LD blocks, NA block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP and all SNP or haplotype P-value > 0.05 in SZ/SZA.. This gene is highly suggestive to BP , not suggestive to SZ/SZA. Positive Comment on Study
Yosifova, A.,2009 SNP: rs362043 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 8)

GO terms by PBA (count: 0)

GO terms by database search (count: 8)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

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Region: chr22:18110331..18146554 View in gBrowse
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