BDgene

PBA Study Report

Basic Info
Reference
Citation Holmans, P., E. K. Green, et al. (2009). "Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder." Am J Hum Genet 85(1): 13-24.
Data Set WTCCC + STEP-UCL + ED-DUB-STEP2
PBA Approach ALIGATOR (Association LIst Go AnnoTatOR)
No. of Reported Pathways 30

Pathways reported by this study (count: 30)
Pathway Source Pathway ID Pathway Name in Paper Result Parameters Gene List
GO GO:0000045 GO:00045: autophagic vacuole formation PROCESS, cutoff for significant SNPs: p < 0.01 PIK3C3
GO GO:0000375 GO:00375: RNA splicing, via transesterification reactions PROCESS, cutoff for significant SNPs: p < 0.01 SLU7 GEMIN2
GO GO:0000377 GO:00377: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile PROCESS, cutoff for significant SNPs: p < 0.01
GO GO:0000398 GO:00398: nuclear mRNA splicing, via spliceosome PROCESS, cutoff for significant SNPs: p < 0.01 SLU7 TFIP11 HNRNPC DGCR14 DHX15 NCBP2
GO GO:0001958 GO:01958: endochondral ossification PROCESS, cutoff for significant SNPs: p < 0.01 MMP16 BMP6 GNAS
GO GO:0002521 GO:02521: leukocyte differentiation PROCESS, cutoff for significant SNPs: p < 0.01
GO GO:0003676 GO:03676: nucleic acid binding FUNCTION, cutoff for significant SNPs: p < 0.01 ZXDC ZNF385D CLIP1 RNASE4 JAZF1
GO GO:0003677 GO:03677: DNA binding FUNCTION, cutoff for significant SNPs: p < 0.01 SP4 TFIP11 PPARD ZKSCAN4 GTF3C5 ZNF680 INO80 RORA MYT1L PAX8 CLOCK PHF20 POLE2 CRY1 EGR4 CDKN2A NFIL3 ARNT2 SURF6 CERS3 RLF SP8 CHD1L ATXN1 ZNF284 BAZ2B TFAP2B YY1 ZNF490 PALB2 AHRR ZBED4 EGR3 ATF4 SOD2 AHR ZNF563 SCML4 EGR1 POLN ZNF678 IRF2 TAL2 CREM XBP1 GFI1B ZNF732 TCF4 LRRFIP1 ZHX2 PBRM1 TRIM26 NCOR2 TCF7L1 TSNAX PRIM2 NPAS3 POU6F2 TEAD1 XRCC4 ZNF626 FBXO18 HMG20A ARID1B RAD51B ZNF74 KAT6B HES1 ZBTB20 HMGXB4 HNF4A ZSCAN31 CRY2 EBF1 FOXP2 RNF4 ZIC2 ARNTL NFIX NPAS2 FOXO3 ZNF236 GSC2
GO GO:0003700 GO:03700: transcription factor activity FUNCTION, cutoff for significant SNPs: p < 0.01 NR3C1 NPAS2 YY1 ZKSCAN4 ZSCAN31 PAX8 MYT1L HES1 POU6F2 ZNF490 ZHX2 EGR1 CREB1 ID1 RORA GLI2 XBP1 FOXN3 TCF4 ZNF274 AHR RNF4 ZIC2 TBP AFF1 PPARD TEAD1 NFIL3 ZXDC ATF4 POU3F2 MKL2 HOXA3 CREBBP HMG20A TCF7L2 CSRNP2 ARNT2 EGR4 ARNTL2 ESR1 FOXO3 MEOX2 RORB TFAM ZNF74 NFIX FOXP2 RFX4 EBF1 TULP4 CREM HSF2 NR3C2 TCF7L1 CLOCK EGR3 THRA TFAP2B GSC2 ELK3 HNF4A NFIA EGR2 GLI3 IRF2
GO GO:0004364 GO:04364: glutathione transferase activity FUNCTION, cutoff for significant SNPs: p < 0.01 GSTZ1 GSTT1 GSTM1
GO GO:0004867 GO:04867: serine-type endopeptidase inhibitor activity FUNCTION, cutoff for significant SNPs: p < 0.01 CRIM1 ITIH1 SERPINA12 ITIH3 SERPINA11 AGT COL28A1
GO GO:0005102 GO:05102 : receptor binding FUNCTION, cutoff for significant SNPs: p < 0.01 DAO DIAPH1 CXCL12 PICK1 NRG1 GFRA1 ITGB8 HLA-B PTPRD GDNF HLA-G HNF4A CHRNA10 UFD1L SLC6A3 DDO ADM LGI1 ADCYAP1 CD276 P2RX4 NRG3 LAMA3 TENM2 ANXA1 TRIM24 PLA2G1B NPPB ARRB2 CRH GJA1 P2RX7 CROT ITK HLA-A NRXN1 CCL2
GO GO:0005179 GO:05179: hormone activity FUNCTION, cutoff for significant SNPs: p < 0.01 CRH CRHR2 IGF1 INHBB NPPB GNRH1 ADM VIP CCK INS AGT SST
GO GO:0005634 GO:05634: nucleus CELLULAR, cutoff for significant SNPs: p < 0.01 SPATS2L GCH1 STK39 ELK3 ANXA1 EGR3 GSK3B CTNND2 CSNK1E TENM4 NFIA AKT1 CTBP2 CSNK1D PPARGC1B ZWINT WWOX CPEB1 ZNF626 ZNF678 SIVA1 PAX8 ZKSCAN4 ZIC2 EGFR ATP1A3 TIPIN DCAF6 APOE ID1 PER2 DHX15 ARNT2 STK24 KAT6B PRPF18 RAD18 DRD1 MYOZ1 DTNBP1 TPP2 BRCA2 DDX27 POU3F2 FABP7 PHF8 WWC1 ZNF236 FST BCL11A TFAP2B NXN ZBTB20 FBXO38 THRA HMG20A CMIP SLU7 CSNK2A1 TRH TSNAX FOXN3 ZNF563 ARNTL DGKH PPP2R5C PAWR YY1 RGS4 KNTC1 PARD6B HSPA1A UBE2L3 CAMK2A LPIN1 TACC2 RFX4 NRG1 NRIP1 PER3 ERCC4 ERBB4 S100B ZNF680 RABGAP1L CRBN PDE4B GLI3 IFRD1 NFIL3 GNAS DBP CREM RNF4 HSPA5 HNF4A LSM11 TDRD9 PPP1R1B RUVBL2 EBF1 SNAI1 PPP2R5D TNR CSRNP2 NAMPT OPTN CREB1 BRE RBFOX1 MTOR TLE4 TCF7L2 NR4A2 FGF12 ATXN1 DST SCML4 POLN NUP214 PIP4K2A MPC2 NLRC5 ADRA1B TCF4 TRIB1 TNK2 BCL2 FOXO3 TH BHLHE41 PIK3C2A PREP USP31 NR3C1 GSC2 SEMG2 CHAT HSP90B1 ZNF274 NIPBL EGR4 ADRB2 FOXP2 TIMELESS RGS17 HSP90AA1 RLF NUF2 DGCR8 RORA KCTD1 NAA38 POU6F2 ATF4 SPAG16 ZRANB1 PIK3R1 RORB NUMB MAB21L1 ADRA1A MKL2 NR1D1 PTPRE TFAM METTL21C ZXDC DSP JAK1 XBP1 PKIB CMTM8 ZNF277 PMCH DGCR6 KAT5 TPX2 RGS7 BASP1 FBXO18 CHCHD3 DGCR6L EGR1 TCF7L1 PRKCE IRF2BP2 NEK5 ARNTL2 CRY1 HECW2 TSPYL4 CIDEA NF1 OTX2 AURKB BRD1 SVIL DGCR14 MED15 RAD51B CRY2 HSF2 CREBBP AHR TXNL1 MAGI2 FYN CAMKMT SACS PPARD CRHBP TRRAP CDKN2A CHD1L ZNF385D DIP2C HNRNPC DLG1 MBNL1 LIMS2 NCBP2 DGKQ ADARB1 MAD1L1 HTT SYNE1 ALKBH8 PALLD CLOCK CAMKK2 XRCC4 EGR2 MBP MED12 HDAC9 ZBED4 NPAS2 ZSCAN31 VRK2 PER1 GRIK4 HES1 BAZ2B ARRB2 UFD1L GEMIN2 MEOX2 TAOK2 GNL3 JAZF1 GLI2 ZNF490 NCOR2 ZNF732 ZNF284 ZNF536 LRRFIP1 MACROD2 TRIM24 NUDCD1 MIPOL1 RBM23 DLC1 MYT1L ESR1 NOS3 ZHX2 RCOR1 QKI SIRT1 GFI1B LSG1 PKIA INO80 SAMSN1 FGFR2 CUX2 TENM2 NOTCH4 NFIX SP8 PARK2
GO GO:0005853 GO:05853: eukaryotic translation elongation factor 1 complex CELLULAR, cutoff for significant SNPs: p < 0.01
GO GO:0006323 GO:06323: DNA packaging PROCESS, cutoff for significant SNPs: p < 0.01
GO GO:0006465 GO:06465: signal peptide processing PROCESS, cutoff for significant SNPs: p < 0.01 PCSK5
GO GO:0006623 GO:06623: protein targeting to vacuole PROCESS, cutoff for significant SNPs: p < 0.01
GO GO:0007034 GO:07034: vacuolar transport PROCESS, cutoff for significant SNPs: p < 0.01 CHMP1B
GO GO:0007076 GO:07076: mitotic chromosome condensation PROCESS, cutoff for significant SNPs: p < 0.01 NCAPD3
GO GO:0008380 GO:08380: RNA splicing PROCESS, cutoff for significant SNPs: p < 0.01 QKI DHX15 HNRNPC MBNL1 GEMIN2 PRPF18 NCBP2 RBFOX1
GO GO:0016236 GO:16236: macroautophagy PROCESS, cutoff for significant SNPs: p < 0.01 PIK3C3 OPTN
GO GO:0018345 GO:18345: protein palmitoylation PROCESS, cutoff for significant SNPs: p < 0.01 ZDHHC8
GO GO:0030098 GO:30098: lymphocyte differentiation PROCESS, cutoff for significant SNPs: p < 0.01
GO GO:0030212 GO:30212: hyaluronan metabolic process PROCESS, cutoff for significant SNPs: p < 0.01 ITIH1 AKT1 ITIH3
GO GO:0030528 GO:30528: transcription regulator activity FUNCTION, cutoff for significant SNPs: p < 0.01
GO GO:0033077 GO:33077: T cell differentiation in the thymus PROCESS, cutoff for significant SNPs: p < 0.01 BCL2 XRCC4 GLI3
GO GO:0033151 GO:33151: V(D)J recombination PROCESS, cutoff for significant SNPs: p < 0.01
GO GO:0042301 GO:42301: phosphate binding FUNCTION, cutoff for significant SNPs: p < 0.01 ADSSL1
GO GO:0044249 GO:44249: cellular biosynthetic process PROCESS, cutoff for significant SNPs: p < 0.01