Gene Report

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Basic Info

Approved Symbol	SCML4
Symbol Alias	dJ47M23.1
Approved Name	sex comb on midleg-like 4 (Drosophila)
Location	6q21
Position	chr6:107704104-107824317, -1
External Links	HGNC: 21397 Entrez Gene: 256380 Ensembl: ENSG00000146285 UCSC: uc010kdf.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010		For gene-based test, P-value = 0.106 in STEP1. non-significant in any samples.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IEA	83
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0006351	transcription, DNA-templated	biological process	IEA	103

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation
rs6903929	chr6:107704933 - 107704933(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs11153074	chr6:107704766 - 107704766(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs11153075	chr6:107704804 - 107704804(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6q16-q21	chr6:100000000-114200000	1 (0/0/1)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q21	chr6:105000000-114200000	4 (1/2/1)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q21-22	chr6:105000000-130000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:107704104..107824317 View in gBrowse