Gene Report

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Basic Info

Approved Symbol	HECW2
Symbol Alias	KIAA1301, NEDL2
Approved Name	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Location	2q32.3
Position	chr2:196194370-196593692, -1
External Links	HGNC: 29853 Entrez Gene: 57520 Ensembl: ENSG00000138411 UCSC: uc002utm.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McQuillin, A.,2011		Gene related CNV occurred in two or more cases but not in controls.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IBA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004842	ubiquitin-protein transferase activity	molecular function	IBA	12
GO:0016874	ligase activity	molecular function	IEA	16
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological process	IBA	4
GO:0005737	cytoplasm	cellular component	IBA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HECW2	TP73	NO	in vitro;in vivo	12890487

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_McQuillin[2011]_6	chr2:196772221-197165580 (NCBI Build 36 (hg18))	393360

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q24-33	chr2:154000000-208200000	1 (1/0/0)
2q32.3-q33	chr2:191100000-208200000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:196194370..196593692 View in gBrowse