Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	NAMPT
Previous Symbol	PBEF1
Symbol Alias	PBEF
Approved Name	nicotinamide phosphoribosyltransferase
Previous Name	pre-B-cell colony enhancing factor 1
Name Alias	visfatin
Location	7q22.3
Position	chr7:106248285-106286326, -1
External Links	HGNC: 30092 Entrez Gene: 10135 Ensembl: ENSG00000105835 UCSC: uc003vdq.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		NAMPT has been implicated in BPD and Lithium response.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 28)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0005125	cytokine activity	molecular function	IEA	13
GO:0007565	female pregnancy	biological process	IEA	15

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006769	nicotinamide metabolic process	biological process	TAS	1
GO:0008144	drug binding	molecular function	IEA	21
GO:0019674	NAD metabolic process	biological process	TAS	1
GO:0014070	response to organic cyclic compound	biological process	IEA	4
GO:0005615	extracellular space	cellular component	IEA	85
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	biological process	IDA[19727662]	4
GO:0005515	protein binding	molecular function	IPI[18486613]	563
GO:0009435	NAD biosynthetic process	biological process	IEA	1
GO:0007267	cell-cell signaling	biological process	TAS[8289818]	29
GO:0008284	positive regulation of cell proliferation	biological process	TAS[8289818]	44
GO:0048661	positive regulation of smooth muscle cell proliferation	biological process	IEA	11
GO:0006766	vitamin metabolic process	biological process	TAS	5
GO:0060612	adipose tissue development	biological process	IDA[17983582]	5
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[23001182]	91
GO:0008286	insulin receptor signaling pathway	biological process	IDA[17983582]	15
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	molecular function	IEA	1
GO:0047280	nicotinamide phosphoribosyltransferase activity	molecular function	IEA	1
GO:0032922	circadian regulation of gene expression	biological process	ISS	22
GO:0007623	circadian rhythm	biological process	TAS	40
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0070062	extracellular vesicular exosome	cellular component	IDA[20458337]	176
GO:0005829	cytosol	cellular component	TAS	223
GO:0007165	signal transduction	biological process	TAS[8289818]	136
GO:0006767	water-soluble vitamin metabolic process	biological process	TAS	5