Gene Report

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Basic Info

Approved Symbol	LSM11
Symbol Alias	FLJ38273
Approved Name	LSM11, U7 small nuclear RNA associated
Previous Name	LSM11 homolog, U7 small nuclear RNA associated (S. cerevisiae)
Location	5q33.3
Position	chr5:157743695-157760709, 1
External Links	HGNC: 30860 Entrez Gene: 134353 Ensembl: ENSG00000155858 UCSC: uc003lxe.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kerner, B.,2009	SNP: rs6882516	Only a small number of families had been informative for those SNPs in the individual data sets, therefore the analysis of all families combined increased the evidence for those loci.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0071204	histone pre-mRNA 3'end processing complex	cellular component	ISS	1
GO:0006398	histone mRNA 3'-end processing	biological process	IBA; ISS	1
GO:0031124	mRNA 3'-end processing	biological process	TAS	2
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0006369	termination of RNA polymerase II transcription	biological process	TAS	2
GO:0008334	histone mRNA metabolic process	biological process	TAS	2
GO:0010467	gene expression	biological process	TAS	41
GO:0005683	U7 snRNP	cellular component	IDA[11574479]; ISS	1
GO:0005515	protein binding	molecular function	IPI[12975319]	563
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	biological process	IMP[16914750]	3
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS	31
GO:0071209	U7 snRNA binding	molecular function	IDA[12975319]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
LSM11	SNRPB	NO	in vivo	12975319
LSM11	LSM10	NO	in vitro;in vivo	12975319
LSM11	ZNF473	NO	in vitro;yeast 2-hybrid	12975319

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6882516	chr5:157755889 - 157755889(1)	3_prime_UTR_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q31-q33	chr5:131200000-160500000	1 (1/0/0)
5q32-5q33.3	chr5:145100000-160500000	1 (0/1/0)
5q33	chr5:150400000-160500000	2 (0/1/1)
5q33-34	chr5:150400000-169000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:157743695..157760709 View in gBrowse