Gene Report

Basic Info
Approved Symbol RBFOX1
Symbol Alias A2BP1, FOX-1, HRNBP1
Approved Name RNA binding protein, fox-1 homolog (C. elegans) 1
Name Alias ataxin 2-binding protein 1, "hexaribonucleotide binding protein 1"
Location 16p13.3
Position chr16:6019094-7713338, 1
External Links HGNC: 18222
Entrez Gene: 54715
Ensembl: ENSG00000078328
UCSC: uc002cyy.2
No. of Studies 6 (Positive: 2; Negative: 2; trend: 2)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 6)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Johnson, C.,2009 Monte-Carlo Simulation P-value = 0.0013. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis Positive Comment on Study
Ollila, H. M.,2009 SNP: rs10500336 It showed no evidence for association with BPI in our study. Negative Comment on Study
Georgieva, L., 2014 A de novo CNV in this gene was detected in BD. Trend Comment on Study
Noor A., 2014 Selected stringent CNV related to this gene is validated by qPCR from BD case data. Positive Comment on Study
Xu, W., 2014 SNP: rs8055744, rs899305 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Hamshere, M. L.,2009 SNP: rs4786811 the nearest gene of one independently associated SNP rs4786811 that exceed a significance threshold of P-value E-05(all of which have good quality clusterplots) Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 12)

GO terms by PBA (count: 2)

GO terms by database search (count: 10)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 64)

Literature-origin SNPs (count: 6)

LD-proxies (count: 58)

Gene related CNVs (count: 3)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr16:6019094..7713338 View in gBrowse
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