Gene Report

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Basic Info

Approved Symbol	NUP214
Symbol Alias	CAIN, CAN, D9S46E, N214
Approved Name	nucleoporin 214kDa
Previous Name	nucleoporin 214kD (CAIN)
Name Alias	nuclear pore complex protein Nup214, "CAN protein, putative oncogene"
Location	9q34
Position	chr9:131125561-131234670, 1
External Links	HGNC: 8064 Entrez Gene: 8021 Ensembl: ENSG00000126883 UCSC: uc004cag.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs6597678	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005215	transporter activity	molecular function	TAS[8108440]	8
GO:0010467	gene expression	biological process	TAS	41
GO:0005925	focal adhesion	cellular component	IDA	32
GO:0015758	glucose transport	biological process	TAS	7
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0005487	nucleocytoplasmic transporter activity	molecular function	IEA	2
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	23
GO:0005975	carbohydrate metabolic process	biological process	TAS	12
GO:0009405	pathogenesis	biological process	TAS	13
GO:0005515	protein binding	molecular function	IPI[11545741]	563
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	34
GO:0006606	protein import into nucleus	biological process	IEA	3
GO:0007077	mitotic nuclear envelope disassembly	biological process	TAS	3
GO:0006611	protein export from nucleus	biological process	IMP[12191473]	3
GO:0008645	hexose transport	biological process	TAS	2
GO:0019058	viral life cycle	biological process	TAS	3
GO:0019083	viral transcription	biological process	TAS	2
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0051726	regulation of cell cycle	biological process	IEA	6
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0005829	cytosol	cellular component	TAS	223
GO:0005643	nuclear pore	cellular component	IEA	3
GO:0006406	mRNA export from nucleus	biological process	IEA	4
GO:0016032	viral process	biological process	TAS	26
GO:0010827	regulation of glucose transport	biological process	TAS	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NUP214	NUP88	YES	in vitro	9488438
NUP214	DDX19B	NO	in vitro	10428971
NUP214	NXF1	NO	in vitro;in vivo	11551912 , 10668806
NUP214	SMAD2	NO	in vitro;in vivo	12191473
NUP214	SMAD4	NO	in vitro	12917407
NUP214	XPOT	NO	in vitro	12138183
NUP214	IPO5	NO	in vitro	9114010
NUP214	XPO1	NO	in vitro;in vivo	11551912
NUP214	SMAD3	NO	in vitro	12917407
NUP214	ZFP36	NO	in vivo;yeast 2-hybrid	14766228
NUP214	TNPO1	NO	in vitro	9144189
NUP214	XPO5	NO	in vitro;in vivo;yeast 2-hybrid	11777942
NUP214	NXF2	NO	in vitro	11073998

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6597678	chr9:131149084 - 131149084(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q33.3-34.3	chr9:123100000-138394717	1 (0/1/0)
9q34	chr9:127500000-138394717	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr9:131125561..131234670 View in gBrowse