Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	FBXO18
Symbol Alias	FBH1, FLJ14590, Fbx18
Approved Name	F-box protein, helicase, 18
Previous Name	F-box only protein 18
Location	10p15.1
Position	chr10:5890203-5937594, 1
External Links	HGNC: 13620 Entrez Gene: 84893 Ensembl: ENSG00000134452 UCSC: uc001iit.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0042. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0003677	DNA binding	molecular function	IEA	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000737	DNA catabolic process, endonucleolytic	biological process	IMP[23361013]	2
GO:0004003	ATP-dependent DNA helicase activity	molecular function	IEA	3
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	biological process	IMP[23361013]	1
GO:0005515	protein binding	molecular function	IPI[23954233]	563
GO:0001934	positive regulation of protein phosphorylation	biological process	IMP[23361013]	15
GO:0072429	response to intra-S DNA damage checkpoint signaling	biological process	IMP[23361013]	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0032508	DNA duplex unwinding	biological process	IEA	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FBXO18	RBX1	YES	in vivo	11956208
FBXO18	SKP1	NO	in vivo	11956208
FBXO18	PIM2	NO	yeast 2-hybrid	16169070
FBXO18	RPL13A	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10p13-p15	chr10:0-17300000	1 (0/1/0)
10p15	chr10:0-6600000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr10:5890203..5937594 View in gBrowse