Gene Report

Basic Info
Approved Symbol ITK
Symbol Alias EMT, PSCTK2, LYK
Approved Name IL2-inducible T-cell kinase
Location 5q31-q32
Position chr5:157142933-157255191, 1
External Links HGNC: 6171
Entrez Gene: 3702
Ensembl: ENSG00000113263
UCSC: uc003lwo.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kerner, B.,2009 SNP: rs452223 Only a small number of families had been informative for those SNPs in the individual data sets, therefore the analysis of all families combined increased the evidence for those loci. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 25)

GO terms by PBA (count: 2)

GO terms by database search (count: 23)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 20)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:157142933..157255191 View in gBrowse
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