Gene Report

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Basic Info

Approved Symbol	PKIB
Previous Symbol	PRKACN2
Approved Name	protein kinase (cAMP-dependent, catalytic) inhibitor beta
Location	6q21-q22.1
Position	chr6:122471917-122726373, 1
External Links	HGNC: 9018 Entrez Gene: 5570 Ensembl: ENSG00000135549 UCSC: uc003pzc.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010	SNP: rs7765860	For gene-based test, P-value = 0.047 in STEP1. nominally significant in STEP1 sample, but not survive Bonferroni correction test.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IBA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004862	cAMP-dependent protein kinase inhibitor activity	molecular function	IBA	4
GO:2000480	negative regulation of cAMP-dependent protein kinase activity	biological process	IBA	4
GO:0005737	cytoplasm	cellular component	IBA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PKIB	DYNLL1	NO	in vivo;yeast 2-hybrid	11978406
PKIB	PRKACB	YES	in vivo	7684369

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7765860	chr6:122636603 - 122636603(1)	downstream_gene_variant; intron_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs9490500	chr6:122622328 - 122622328(1)	intron_variant; non_coding_transcript_variant
rs7752438	chr6:122659366 - 122659366(1)	intron_variant
rs7769704	chr6:122677447 - 122677447(1)	intron_variant
rs13193040	chr6:122652287 - 122652287(1)	intron_variant; upstream_gene_variant
rs2316962	chr6:122657277 - 122657277(1)	intron_variant
rs11154100	chr6:122629928 - 122629928(1)	intron_variant; non_coding_transcript_variant
rs1430815	chr6:122647266 - 122647266(1)	downstream_gene_variant; intron_variant
rs9490509	chr6:122646024 - 122646024(1)	downstream_gene_variant; intron_variant
rs2815597	chr6:122670471 - 122670471(1)	intron_variant
rs6914480	chr6:122628764 - 122628764(1)	intron_variant; non_coding_transcript_variant
rs6919740	chr6:122635417 - 122635417(1)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q22.1-6q22.33	chr6:114200000-130000000	1 (0/1/0)
6q21-22	chr6:105000000-130000000	1 (0/0/1)
6q22	chr6:114200000-130000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:122471917..122726373 View in gBrowse