Gene Report

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Basic Info

Approved Symbol	TAL2
Symbol Alias	bHLHa19
Approved Name	T-cell acute lymphocytic leukemia 2
Location	9q32
Position	chr9:105662457-105663112, 1
External Links	HGNC: 11557 Entrez Gene: 6887 Ensembl: ENSG00000186051 UCSC: uc004bct.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Winham S.J., 2014	SNP: rs10491807	It showed little evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IEA	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0009791	post-embryonic development	biological process	IEA	10
GO:0021794	thalamus development	biological process	IEA	2
GO:0030901	midbrain development	biological process	IEA	6
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0035264	multicellular organism growth	biological process	IEA	9
GO:0046983	protein dimerization activity	molecular function	IEA	19

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TAL2	TCF3	NO	in vivo	8152805
TAL2	MAPK3	NO	in vitro	8152805
TAL2	LMO1	NO	in vivo	7957052
TAL2	LMO2	NO	in vivo	7957052

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10491807	chr9:105653445 - 105653445(1)	upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
9q21-32	chr9:65000000-114900000	1 (0/1/0)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q31	chr9:99800000-112100000	6 (0/4/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr9:105662457..105663112 View in gBrowse