Gene Report

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Basic Info

Approved Symbol	NPPB
Approved Name	natriuretic peptide B
Previous Name	natriuretic peptide precursor B
Location	1p36.2
Position	chr1:11857464-11858931, -1
External Links	HGNC: 7940 Entrez Gene: 4879 Ensembl: ENSG00000120937 UCSC: uc001atj.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs6668659	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	IDA[1672777]; IPI[12727915]	37
GO:0005179	hormone activity	molecular function	NAS[7601467]	12

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006182	cGMP biosynthetic process	biological process	IDA[1672777]	2
GO:0042312	regulation of vasodilation	biological process	NAS[7601467]	4
GO:0008217	regulation of blood pressure	biological process	NAS[12727915]	12
GO:0005615	extracellular space	cellular component	NAS[7601467]	85
GO:0016525	negative regulation of angiogenesis	biological process	TAS[14737067]	5
GO:0008613	diuretic hormone activity	molecular function	TAS[14960748]	1
GO:0050880	regulation of blood vessel size	biological process	IEA	5
GO:0035810	positive regulation of urine volume	biological process	TAS[14737067]	3
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0035815	positive regulation of renal sodium excretion	biological process	TAS[14960748]	5
GO:0043234	protein complex	cellular component	IDA[23382219]	27
GO:0007589	body fluid secretion	biological process	TAS[14960748]	2
GO:0007166	cell surface receptor signaling pathway	biological process	NAS[12727915]	23
GO:0007168	receptor guanylyl cyclase signaling pathway	biological process	IDA[1672777]	1
GO:0043114	regulation of vascular permeability	biological process	TAS[14737067]	2
GO:0030308	negative regulation of cell growth	biological process	NAS[12727915]	11
GO:0005576	extracellular region	cellular component	TAS[14960748]	97

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
alkPathway	ALK in cardiac myocytes	2

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NPPB	EWSR1	NO	yeast 2-hybrid	16189514
NPPB	NPR3	NO	in vitro;in vivo	1309330 , 7901875
NPPB	NPR1	NO	in vitro;in vivo	7901875 , 1309330

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6668659	chr1:11862241 - 11862241(1)	upstream_gene_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs12406089		chr1:11861124 - 11861124(1)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p35-p36	chr1:0-34300000	1 (1/0/0)
1p33-p36	chr1:0-50200000	1 (0/0/1)
1p36.22	chr1:9100000-12500000	1 (0/0/1)
1p36	chr1:0-27600000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:11857464..11858931 View in gBrowse