Gene Report

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Basic Info

Approved Symbol	PKIA
Previous Symbol	PRKACN1
Approved Name	protein kinase (cAMP-dependent, catalytic) inhibitor alpha
Location	8q21.13
Position	chr8:78516139-78605267, 1
External Links	HGNC: 9017 Entrez Gene: 5569 Ensembl: ENSG00000171033 UCSC: uc003ybb.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Djurovic, S.,2010	SNP: rs1510122, rs264826, rs448245	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IBA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042308	negative regulation of protein import into nucleus	biological process	IEA	2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	62
GO:0005737	cytoplasm	cellular component	IBA	322
GO:0010389	regulation of G2/M transition of mitotic cell cycle	biological process	IEA	2
GO:2000480	negative regulation of cAMP-dependent protein kinase activity	biological process	IDA[21812984]	4
GO:0034236	protein kinase A catalytic subunit binding	molecular function	IPI[21812984]	4
GO:0004862	cAMP-dependent protein kinase inhibitor activity	molecular function	IDA[21812984]; TAS[1710219]	4
GO:0005515	protein binding	molecular function	IPI[20485264]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PKIA	PRKACA	NO	in vitro	8027074 , 7905001
PKIA	DYNLL1	NO	in vivo;yeast 2-hybrid	11978406
PKIA	PRKX	NO	in vitro	10026146
PKIA	AGFG1	NO	yeast 2-hybrid	8805303

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1510122	chr8:77653293 - 77653293(1)		1(0/1/0)
rs448245	chr8:77600338 - 77600338(1)		1(0/1/0)
rs264826	chr8:77458426 - 77458426(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q12.1-q22.1	chr8:54600000-97900000	1 (1/0/0)
8p11.21-q21.13	chr8:39900000-83500000	1 (1/0/0)
8q13.3-21.13	chr8:69600000-83500000	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
24391664	GPLS genes significantly dysregulated in anterior cingulate cortex by microarray	Pos	PKIA

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Region: chr8:78516139..78605267 View in gBrowse