Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ZNF277
Previous Symbol	ZNF277P
Symbol Alias	NRIF4
Approved Name	zinc finger protein 277
Previous Name	zinc finger protein (C2H2 type) 277, "zinc finger protein 277 pseudogene"
Location	7q31.1
Position	chr7:112206588-112343096, 1
External Links	HGNC: 13070 Entrez Gene: 11179 Ensembl: ENSG00000198839 UCSC: uc003vge.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		ZNF277 has been related to mental competency.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

GO terms by database search (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2000772	regulation of cellular senescence	biological process	IEA	3
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	molecular function	IEA	9
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0070301	cellular response to hydrogen peroxide	biological process	IEA	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ZNF277	COIL	NO	yeast 2-hybrid	16713569

Related other genetic factors

Gene related SNPs (count: 17)

Literature-origin SNPs (count: 0)

LD-proxies (count: 17)

rs_ID	Location	Functional Annotation
rs2249157	chr7:112346618 - 112346618(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs4730529	chr7:112336859 - 112336859(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs886353	chr7:112347498 - 112347498(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs16873374	chr7:112203375 - 112203375(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs2249151	chr7:112346748 - 112346748(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs7795336	chr7:112233702 - 112233702(1)	intron_variant; NMD_transcript_variant
rs3807884	chr7:112205718 - 112205718(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs10272976	chr7:112326985 - 112326985(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs4730516	chr7:112240115 - 112240115(1)	intron_variant; NMD_transcript_variant
rs11768608	chr7:112237838 - 112237838(1)	intron_variant; NMD_transcript_variant
rs7781245	chr7:112255626 - 112255626(1)	intron_variant; NMD_transcript_variant
rs10953708	chr7:112244933 - 112244933(1)	intron_variant; NMD_transcript_variant
rs11769219	chr7:112315893 - 112315893(1)	intron_variant; NMD_transcript_variant
rs10238141	chr7:112276268 - 112276268(1)	intron_variant; NMD_transcript_variant
rs11773393	chr7:112330287 - 112330287(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; stop_retained_variant
rs3823515	chr7:112318284 - 112318284(1)	intron_variant; NMD_transcript_variant
rs6955231	chr7:112341824 - 112341824(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q31-33	chr7:107800000-138500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:112206588..112343096 View in gBrowse