Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	VIP
Approved Name	vasoactive intestinal peptide
Name Alias	prepro-VIP
Location	6q24-q27
Position	chr6:152750798-152759765, 1
External Links	HGNC: 12693 Entrez Gene: 7432 Ensembl: ENSG00000146469 UCSC: uc003qpe.5
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Soria, V.,2010	SNP: rs17083008, rs688136	Significant associations of VIP gene were found in BPD patients.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 22)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005179	hormone activity	molecular function	IDA[9603988]	12

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045732	positive regulation of protein catabolic process	biological process	IDA[9603988]	4
GO:0043066	negative regulation of apoptotic process	biological process	IEA	46
GO:0009966	regulation of signal transduction	biological process	IEA	4
GO:0048255	mRNA stabilization	biological process	ISS	2
GO:0007611	learning or memory	biological process	IEA	13
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[10096039]	64
GO:0005184	neuropeptide hormone activity	molecular function	TAS[10096039]	8
GO:0070459	prolactin secretion	biological process	ISS	2
GO:0005576	extracellular region	cellular component	TAS	97
GO:0005515	protein binding	molecular function	IPI[21314817]	563
GO:0001938	positive regulation of endothelial cell proliferation	biological process	IEA	11
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological process	IDA[9603988]	16
GO:0007589	body fluid secretion	biological process	TAS[4035357]	2
GO:0060406	positive regulation of penile erection	biological process	IEA	3
GO:0051930	regulation of sensory perception of pain	biological process	IEA	7
GO:0043267	negative regulation of potassium ion transport	biological process	IEA	6
GO:0032880	regulation of protein localization	biological process	IDA[9603988]	4
GO:0045909	positive regulation of vasodilation	biological process	IEA	14
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IEA	7
GO:0008284	positive regulation of cell proliferation	biological process	TAS[8389448]	44

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
vipPathway	Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells	9

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
VIP	MME	NO	in vitro	9313778
VIP	PRICKLE1	NO	in vivo	15009665
VIP	VIPR2	YES	in vitro;in vivo	8146174 , 9454823 , 10801840
VIP	UBQLN4	NO	yeast 2-hybrid	16713569
VIP	VIPR1	NO	in vivo	15247290 , 807467 , 11027527

Related other genetic factors

Gene related SNPs (count: 5)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs688136	chr6:152758926 - 152758926(1)	3_prime_UTR_variant	1(1/0/0)
rs17083008	chr6:152746792 - 152746792(1)	upstream_gene_variant	1(1/0/0)

LD-proxies (count: 3)

rs_ID	Location	Functional Annotation
rs627728	chr6:152761234 - 152761234(1)	downstream_gene_variant
rs664355	chr6:152762275 - 152762275(1)	downstream_gene_variant
rs3823082	chr6:152753187 - 152753187(1)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q25.2	chr6:152100000-155200000	1 (0/1/0)
6q25	chr6:148500000-160600000	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20072116	No significant associations of VIP gene were found in MDD patients.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr6:152750798..152759765 View in gBrowse