Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	KAT5
Previous Symbol	HTATIP
Symbol Alias	TIP60, PLIP, cPLA2, HTATIP1, ESA1, ZC2HC5
Approved Name	K(lysine) acetyltransferase 5
Previous Name	HIV-1 Tat interactive protein, 60kDa
Name Alias	Tat interacting protein, 60kDa, "K-acetyltransferase 5"
Location	11q13
Position	chr11:65711996-65719604, 1
External Links	HGNC: 5275 Entrez Gene: 10524 Ensembl: ENSG00000172977 UCSC: uc001ofk.3
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Pae, C. U.,2004(b)	Other variant: KAT5_BanI polymorphism	The polymorphism was not different between BID patients and controls in genotype and allele distribution.	Negative	Comment on Study
Meira-Lima, I.,2003(a)	Other variant: cPLA2_BanI dimorphic site	Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 33)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[17996965]	283

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[17360565]	43
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IMP[17360565]	62
GO:0032403	protein complex binding	molecular function	IEA	16
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	50
GO:0010212	response to ionizing radiation	biological process	IDA[18397884]	2
GO:0070491	repressing transcription factor binding	molecular function	IPI[17360565]	4
GO:0005829	cytosol	cellular component	IEA	223
GO:0071392	cellular response to estradiol stimulus	biological process	IDA[23637611]	8
GO:0003713	transcription coactivator activity	molecular function	IDA[14966270]; TAS[17360565]	22
GO:0016032	viral process	biological process	IEA	26
GO:0040008	regulation of growth	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[15383276]	563
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0000812	Swr1 complex	cellular component	IDA[24463511]	3
GO:0006325	chromatin organization	biological process	TAS	14
GO:0035267	NuA4 histone acetyltransferase complex	cellular component	IDA[10966108]	3
GO:0050681	androgen receptor binding	molecular function	NAS[15572661]	4
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IMP[23637611]	91
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0005730	nucleolus	cellular component	IDA[16387653]	28
GO:0006302	double-strand break repair	biological process	IMP[10966108]	6
GO:0016573	histone acetylation	biological process	IDA[10966108]	5
GO:0030521	androgen receptor signaling pathway	biological process	NAS[15572661]	5
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[14966270]; NAS[15572661]	58
GO:0004402	histone acetyltransferase activity	molecular function	IDA[18397884]; IDA[14966270]; IMP[17996965]	5
GO:0005667	transcription factor complex	cellular component	IEA	18
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	biological process	IDA[14966270]	2
GO:0032703	negative regulation of interleukin-2 production	biological process	IDA[17360565]	1
GO:1901985	positive regulation of protein acetylation	biological process	IDA[24012345]	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	IMP[18397884]	13
GO:0032777	Piccolo NuA4 histone acetyltransferase complex	cellular component	IDA[14966270]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 75)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
KAT5	E2F1	NO	in vitro	15121871
KAT5	GAPDH	NO	yeast 2-hybrid	15383276
KAT5	IL9R	NO	in vivo;yeast 2-hybrid	10486269
KAT5	CCT7	NO	yeast 2-hybrid	16169070
KAT5	PLA2G4A	NO	in vivo;yeast 2-hybrid	11416127
KAT5	C7orf20	NO	yeast 2-hybrid	16169070
KAT5	FAM101B	NO	yeast 2-hybrid	16169070
KAT5	HDAC1	NO	in vivo	11994312
KAT5	CRELD1	NO	yeast 2-hybrid	16169070
KAT5	STAT3	NO	in vivo	12551922
KAT5	HNRNPH3	NO	yeast 2-hybrid	16169070
KAT5	H3F3B	NO	in vitro	10096020
KAT5	IK	NO	in vitro;yeast 2-hybrid	16169070
KAT5	ETV6	NO	in vitro;in vivo;yeast 2-hybrid	12737628
KAT5	ZNF24	NO	in vitro;yeast 2-hybrid	16169070
KAT5	KIAA1377	NO	in vitro;yeast 2-hybrid	15383276
KAT5	CDC42	NO	yeast 2-hybrid	16169070
KAT5	CCNB1	NO	in vitro;in vivo	12468530
KAT5	HABP4	NO	yeast 2-hybrid	16455055
KAT5	SNRPD2	NO	yeast 2-hybrid	16169070
KAT5	EP300	NO	in vivo	16001085
KAT5	BARD1	NO	yeast 2-hybrid	15383276
KAT5	MAD2L1BP	NO	yeast 2-hybrid	16169070
KAT5	AR	NO	in vitro;in vivo;yeast 2-hybrid	11994312 , 10364196
KAT5	PITX2	NO	in vivo	12464179
KAT5	CDK5RAP2	NO	yeast 2-hybrid	16169070
KAT5	C1orf174	NO	yeast 2-hybrid	16169070
KAT5	POLR3F	NO	in vitro;yeast 2-hybrid	16169070
KAT5	FAM173A	NO	yeast 2-hybrid	16169070
KAT5	LRP1	NO	in vitro;in vivo	12888553
KAT5	PLEKHA4	NO	yeast 2-hybrid	16169070
KAT5	TRIB3	NO	in vitro;yeast 2-hybrid	16169070
KAT5	CBX8	NO	yeast 2-hybrid	16169070
KAT5	LMNA	NO	in vitro;yeast 2-hybrid	16169070
KAT5	HIST2H4A	NO	in vitro	10096020
KAT5	BCL3	NO	in vitro;in vivo;yeast 2-hybrid	10362352 , 15829968
KAT5	POLE2	YES	in vitro;yeast 2-hybrid	16169070
KAT5	NDUFV2	YES	yeast 2-hybrid	16169070
KAT5	CCDC106	NO	yeast 2-hybrid	16169070
KAT5	DLEU1	YES	in vitro;yeast 2-hybrid	16169070
KAT5	HDAC7	NO	in vivo	12551922
KAT5	HIST2H2AC	NO	in vitro	10096020
KAT5	OGFOD2	NO	yeast 2-hybrid	16169070
KAT5	CREB1	YES	in vitro;in vivo	10720489
KAT5	TELO2	NO	yeast 2-hybrid	16169070
KAT5	PDCD5	NO	yeast 2-hybrid	16169070
KAT5	EFNA1	NO	yeast 2-hybrid	16169070
KAT5	PTPRS	NO	in vitro;yeast 2-hybrid	16169070
KAT5	CDK1	NO	in vitro;in vivo	12468530
KAT5	NDUFA4L2	NO	yeast 2-hybrid	16169070
KAT5	ZEB1	NO	yeast 2-hybrid	11275565
KAT5	CSTF2	NO	yeast 2-hybrid	16169070
KAT5	ALOX12	YES	in vivo	15474031
KAT5	MYC	NO	in vitro;in vivo	12776177 , 15572685
KAT5	APP	NO	in vivo	12032152
KAT5	NAP1L5	NO	yeast 2-hybrid	16169070 , 16189514
KAT5	RGL2	NO	yeast 2-hybrid	16169070
KAT5	ARIH2	NO	yeast 2-hybrid	16169070
KAT5	MDM2	NO	in vitro;in vivo	11927554
KAT5	ATXN1	YES	in vitro;in vivo	17110330
KAT5	GSTO1	NO	yeast 2-hybrid	16169070
KAT5	GADD45G	NO	in vitro;yeast 2-hybrid	15383276
KAT5	EDNRA	NO	in vitro;in vivo;yeast 2-hybrid	11262386
KAT5	SNAPIN	NO	yeast 2-hybrid	16169070
KAT5	HAP1	NO	in vitro;yeast 2-hybrid	15383276
KAT5	GEMIN7	NO	yeast 2-hybrid	16169070
KAT5	NFKB1	NO	in vivo	15829968
KAT5	PTPN4	NO	in vitro;yeast 2-hybrid	16169070
KAT5	BMI1	NO	yeast 2-hybrid	16169070
KAT5	SAT1	NO	yeast 2-hybrid	16169070
KAT5	SYN1	NO	yeast 2-hybrid	16169070
KAT5	TP53	NO	in vivo	16601686
KAT5	ATM	NO	in vitro;in vivo	16141325
KAT5	APBB1	NO	in vitro;yeast 2-hybrid	11441186
KAT5	FAM135B	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
KAT5_BanI polymorphism	point mutation		1 (0/1/0)
cPLA2_BanI dimorphic site	point mutation		1 (0/1/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)
11p13-q13.3	chr11:31000000-70500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
15118355	Genotype and allele distributions in MDD patients were significantly different from those of the controls.	Positive

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr11:65711996..65719604 View in gBrowse