Gene Report

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Basic Info

Approved Symbol	DIP2C
Previous Symbol	KIAA0934
Approved Name	DIP2 disco-interacting protein 2 homolog C (Drosophila)
Previous Name	KIAA0934
Location	10p15.3
Position	chr10:274190-689668, -1
External Links	HGNC: 29150 Entrez Gene: 22982 Ensembl: ENSG00000151240 UCSC: uc001ifp.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs3922851	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008134	transcription factor binding	molecular function	IEA	28
GO:0003824	catalytic activity	molecular function	IEA	5
GO:0003674	molecular_function	molecular function	ND	24
GO:0008152	metabolic process	biological process	IEA	50
GO:0008150	biological_process	biological process	ND	24
GO:0005575	cellular_component	cellular component	ND	19

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3922851	chr10:361644 - 361644(1)	downstream_gene_variant; intron_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs7070654		chr10:331221 - 331221(1)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10p13-p15	chr10:0-17300000	1 (0/1/0)
10p15	chr10:0-6600000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
18068248	Genes differentially expressed in major depression	Pos	DIP2C

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Region: chr10:274190..689668 View in gBrowse