Gene Report

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Basic Info

Approved Symbol	METTL21C
Previous Symbol	C13orf39
Symbol Alias	LOC196541
Approved Name	methyltransferase like 21C
Previous Name	chromosome 13 open reading frame 39
Location	13q33.1
Position	chr13:102685744-102694504, -1
External Links	HGNC: 33717 Entrez Gene: 196541 Ensembl: ENSG00000139780 UCSC: uc001vpj.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs3885617	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0018022	peptidyl-lysine methylation	biological process	IDA[22948820]	2
GO:0006479	protein methylation	biological process	IDA[22948820]	2
GO:0016279	protein-lysine N-methyltransferase activity	molecular function	IDA[22948820]	1
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3885617	chr13:102694092 - 102694092(1)	intron_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs7981120		chr13:102694309 - 102694309(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q33.1-q33.3	chr13:101100000-109600000	1 (0/1/0)
13q21-33	chr13:54700000-109600000	1 (0/0/1)
13q31-q34	chr13:78500000-114364328	1 (0/0/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr13:102685744..102694504 View in gBrowse