Gene Report

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Basic Info

Approved Symbol	PPP2R5C
Symbol Alias	B56G, PR61G
Approved Name	protein phosphatase 2, regulatory subunit B', gamma
Previous Name	protein phosphatase 2, regulatory subunit B (B56), gamma isoform, "protein phosphatase 2, regulatory subunit B', gamma isoform"
Location	14q32.31
Position	chr14:101761798-101927989, 1
External Links	HGNC: 9311 Entrez Gene: 5527 Ensembl: ENSG00000078304 UCSC: uc001ykk.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs4900525	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[8703017]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008285	negative regulation of cell proliferation	biological process	IDA[17245430]	41
GO:0005515	protein binding	molecular function	IPI[1328865]	563
GO:0000775	chromosome, centromeric region	cellular component	IDA[16580887]	2
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	IDA[17245430]	2
GO:0000159	protein phosphatase type 2A complex	cellular component	IDA[17174897]; NAS[8703017]	5
GO:0008601	protein phosphatase type 2A regulator activity	molecular function	IDA[17245430]; NAS[8703017]	5
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	IMP[17245430]	3
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	IMP[16717086]	13
GO:0050790	regulation of catalytic activity	biological process	IDA[17245430]; IEA; NAS[8703017]	11
GO:0007165	signal transduction	biological process	NAS[8703017]	136

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP2R5C	PPP2R1B	YES	in vivo	11929880
PPP2R5C	AXIN1	NO	in vivo	10698523
PPP2R5C	PPP2CA	NO	in vivo	11929880
PPP2R5C	SGOL1	NO	in vivo	16541024 , 16541025
PPP2R5C	PRKCD	NO	in vitro;in vivo	11959144
PPP2R5C	EP300	NO	in vitro;in vivo	15632055
PPP2R5C	PXN	NO	in vivo	10675325
PPP2R5C	IER3	YES	in vitro	16456541
PPP2R5C	CHEK2	NO	in vitro;in vivo;yeast 2-hybrid	15380617

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4900525	chr14:101938404 - 101938404(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:101761798..101927989 View in gBrowse