Gene Report

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Basic Info

Approved Symbol	PPP2R5C
Symbol Alias	B56G, PR61G
Approved Name	protein phosphatase 2, regulatory subunit B', gamma
Previous Name	protein phosphatase 2, regulatory subunit B (B56), gamma isoform, "protein phosphatase 2, regulatory subunit B', gamma isoform"
Location	14q32.31
Position	chr14:101761798-101927989, 1
External Links	HGNC: 9311 Entrez Gene: 5527 Ensembl: ENSG00000078304 UCSC: uc001ykk.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs4900525	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[8703017]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008285	negative regulation of cell proliferation	biological process	IDA[17245430]	41
GO:0005515	protein binding	molecular function	IPI[1328865]	563
GO:0000775	chromosome, centromeric region	cellular component	IDA[16580887]	2
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	IDA[17245430]	2
GO:0000159	protein phosphatase type 2A complex	cellular component	IDA[17174897]; NAS[8703017]	5
GO:0008601	protein phosphatase type 2A regulator activity	molecular function	IDA[17245430]; NAS[8703017]	5
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	IMP[17245430]	3
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	IMP[16717086]	13
GO:0050790	regulation of catalytic activity	biological process	IDA[17245430]; IEA; NAS[8703017]	11
GO:0007165	signal transduction	biological process	NAS[8703017]	136

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP2R5C	PRKCD	NO	in vitro;in vivo	11959144
PPP2R5C	PPP2R1B	YES	in vivo	11929880
PPP2R5C	CHEK2	NO	in vitro;in vivo;yeast 2-hybrid	15380617
PPP2R5C	PXN	NO	in vivo	10675325
PPP2R5C	PPP2CA	NO	in vivo	11929880
PPP2R5C	SGOL1	NO	in vivo	16541024 , 16541025
PPP2R5C	AXIN1	NO	in vivo	10698523
PPP2R5C	IER3	YES	in vitro	16456541
PPP2R5C	EP300	NO	in vitro;in vivo	15632055

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4900525	chr14:101938404 - 101938404(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:101761798..101927989 View in gBrowse