Gene Report

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Basic Info

Approved Symbol	RAD51B
Previous Symbol	RAD51L1
Symbol Alias	REC2, hREC2, R51H2
Approved Name	RAD51 paralog B
Previous Name	RAD51 (S. cerevisiae)-like 1, "RAD51-like 1 (S. cerevisiae)", "RAD51 homolog B (S. cerevisiae)"
Location	14q23-q24.2
Position	chr14:67819779-68730218, 1
External Links	HGNC: 9822 Entrez Gene: 5890 Ensembl: ENSG00000182185 UCSC: uc001xkf.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs7149343	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	TAS[9512535]	283
GO:0003677	DNA binding	molecular function	TAS[9512535]	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007131	reciprocal meiotic recombination	biological process	TAS[9441753]	2
GO:0000400	four-way junction DNA binding	molecular function	IDA[20207730]	2
GO:0000724	double-strand break repair via homologous recombination	biological process	IMP[23149936]	9
GO:0003690	double-stranded DNA binding	molecular function	IDA[12441335]	4
GO:0008094	DNA-dependent ATPase activity	molecular function	IDA[12441335]	1
GO:0005657	replication fork	cellular component	IDA[20207730]	2
GO:0006310	DNA recombination	biological process	TAS[9512535]	2
GO:0007596	blood coagulation	biological process	TAS	44
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0005515	protein binding	molecular function	IPI[11751635]	563
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex	cellular component	IDA[11751635]	1
GO:0003697	single-stranded DNA binding	molecular function	IDA[12441335]	7
GO:0006281	DNA repair	biological process	TAS[9512535]	16
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	biological process	IMP[23108668]	1
GO:0005524	ATP binding	molecular function	IEA	118

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa03440	Homologous recombination	3

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7149343	chr14:68097994 - 68097994(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs7148799	chr14:68116911 - 68116911(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs7147522	chr14:68110208 - 68110208(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs11158721	chr14:68129118 - 68129118(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs11158720	chr14:68128912 - 68128912(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7147935	chr14:68132834 - 68132834(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs7359083	chr14:68103744 - 68103744(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs17104917	chr14:68104867 - 68104867(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs8007347	chr14:68109330 - 68109330(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q24	chr14:67400000-78800000	1 (0/0/1)
14q24.1-q32.12	chr14:67400000-94200000	1 (0/0/1)
14q22-24	chr14:50400000-78800000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)
14q13.1-q24.1	chr14:32900000-69800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:67819779..68730218 View in gBrowse