Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CRY1
Previous Symbol	PHLL1
Approved Name	cryptochrome circadian clock 1
Previous Name	cryptochrome 1 (photolyase-like)
Location	12q23-q24.1
Position	chr12:106991364-107093829, -1
External Links	HGNC: 2384 Entrez Gene: 1407 Ensembl: ENSG00000008405 UCSC: uc001tmi.4
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Soria, V.,2010	SNP: rs2287161, rs4640029, rs714359	Significant associations of CRY1 gene were found in BPD patients.	Positive	Comment on Study
Mansour, H. A., 2006		No significant association was detected in any sample using any test.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 40)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	TAS[9801304]	83
GO:0005634	nucleus	cellular component	ISS	283

GO terms by database search (count: 38)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043153	entrainment of circadian clock by photoperiod	biological process	ISS	3
GO:0006975	DNA damage induced protein phosphorylation	biological process	ISS	2
GO:0003904	deoxyribodipyrimidine photo-lyase activity	molecular function	IDA[8909283]	2
GO:0007623	circadian rhythm	biological process	TAS	40
GO:0032868	response to insulin	biological process	IEA	10
GO:0035257	nuclear hormone receptor binding	molecular function	IPI[22170608]	5
GO:0009785	blue light signaling pathway	biological process	NAS[8909283]	2
GO:0006281	DNA repair	biological process	IEA	16
GO:0018298	protein-chromophore linkage	biological process	IEA	2
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:2000001	regulation of DNA damage checkpoint	biological process	ISS	1
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	biological process	ISS	5
GO:0006094	gluconeogenesis	biological process	ISS	4
GO:0019901	protein kinase binding	molecular function	IEA	29
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[12397359]	62
GO:0000166	nucleotide binding	molecular function	IEA	17
GO:0009882	blue light photoreceptor activity	molecular function	NAS[8909283]	2
GO:0031397	negative regulation of protein ubiquitination	biological process	ISS	6
GO:2000850	negative regulation of glucocorticoid secretion	biological process	IEA	1
GO:0042826	histone deacetylase binding	molecular function	IEA	13
GO:0001047	core promoter binding	molecular function	ISS	8
GO:0042593	glucose homeostasis	biological process	ISS	19
GO:0019902	phosphatase binding	molecular function	IPI[9383998]	9
GO:0033762	response to glucagon	biological process	ISS	3
GO:0042752	regulation of circadian rhythm	biological process	ISS	12
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0042754	negative regulation of circadian rhythm	biological process	ISS	3
GO:0032922	circadian regulation of gene expression	biological process	ISS	22
GO:0008134	transcription factor binding	molecular function	IEA	28
GO:0005515	protein binding	molecular function	IPI[17463251]	563
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[12397359]; ISS	43
GO:0003690	double-stranded DNA binding	molecular function	IDA[9801304]	4
GO:0003914	DNA (6-4) photolyase activity	molecular function	IDA[8909283]	2
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IEA	10
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	biological process	ISS	2
GO:0043130	ubiquitin binding	molecular function	ISS	5
GO:0019915	lipid storage	biological process	IEA	4
GO:0000989	transcription factor binding transcription factor activity	molecular function	IDA[15147242]	4

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04710	Circadian rhythm	11

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
circadianPathway	Circadian Rhythms	6

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CRY1	CBLB	NO	yeast 2-hybrid	16189514
CRY1	KRTAP4-12	NO	yeast 2-hybrid	16189514
CRY1	MDFI	NO	yeast 2-hybrid	16189514
CRY1	TRAF2	NO	yeast 2-hybrid	16189514
CRY1	PLSCR1	NO	yeast 2-hybrid	16189514
CRY1	PER3	YES	in vivo	10428031
CRY1	PER2	YES	in vitro;in vivo;yeast 2-hybrid	11533252 , 10531061 , 10428031
CRY1	ARNTL	YES	yeast 2-hybrid	10531061

Related other genetic factors

Gene related SNPs (count: 4)

Literature-origin SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4640029	chr12:106984946 - 106984946(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs2287161	chr12:106987362 - 106987362(1)	downstream_gene_variant; upstream_gene_variant	1(1/0/0)
rs714359	chr12:106985067 - 106985067(1)	downstream_gene_variant; intron_variant	1(0/1/0)

LD-proxies (count: 1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs2287162		chr12:106987127 - 106987127(1)	5_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q23-q24	chr12:95800000-133275309	3 (2/0/1)
12q23	chr12:95800000-108600000	2 (0/1/1)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20072116	Significant associations of CRY1 gene were found in MDD patients.	Positive

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr12:106991364..107093829 View in gBrowse