Gene Report

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Basic Info

Approved Symbol	RCOR1
Previous Symbol	RCOR
Symbol Alias	COREST, KIAA0071
Approved Name	REST corepressor 1
Previous Name	REST corepressor
Location	14q32.33
Position	chr14:102592661-102730576, 1
External Links	HGNC: 17441 Entrez Gene: 23186 Ensembl: ENSG00000089902 UCSC: uc001ymb.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs4906236 Other variant: RCOR1_Chr14:102250649	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[10734093]; NAS[10449787]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[17555596]	17
GO:0017053	transcriptional repressor complex	cellular component	IDA[10734093]	5
GO:0005515	protein binding	molecular function	IPI[10449787]	563
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	IDA[10449787]	14
GO:0070933	histone H4 deacetylation	biological process	IDA[17555596]	2
GO:0007596	blood coagulation	biological process	TAS	44
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[10449787]	43
GO:0045654	positive regulation of megakaryocyte differentiation	biological process	IEA	1
GO:0030218	erythrocyte differentiation	biological process	IEA	3
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[10449787]	62
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0003682	chromatin binding	molecular function	IEA	23
GO:0016032	viral process	biological process	IEA	26
GO:0006325	chromatin organization	biological process	TAS	14

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RCOR1	REST	NO	in vitro;in vivo;yeast 2-hybrid	10449787
RCOR1	SMARCE1	NO	in vitro;in vivo;yeast 2-hybrid	12192000
RCOR1	KDM1A	NO	in vitro	17537733
RCOR1	PHF21A	NO	in vitro	15325272
RCOR1	HDAC2	NO	in vitro;in vivo	11171972

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4906236	chr14:102610905 - 102610905(1)	intron_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
RCOR1_Chr14:102250649		Exonic	1 (0/0/1)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:102592661..102730576 View in gBrowse