Gene Report

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Basic Info

Approved Symbol	GSTZ1
Symbol Alias	GSTZ1-1, MAAI, MAI
Approved Name	glutathione S-transferase zeta 1
Previous Name	glutathione transferase zeta 1
Name Alias	maleylacetoacetate isomerase
Location	14q24.3
Position	chr14:77320884-77331597, 1
External Links	HGNC: 4643 Entrez Gene: 2954 Ensembl: ENSG00000100577 UCSC: uc001xtj.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Rezaei, Z.,2012	Haplotype: GSTZ1_ - 1002A - GSTZ1_32Glu - GSTZ1_42Gly(G-Glu-Gly)	Our present findings supported the association between polymorphisms of GSTZ1 and susceptibility to early-onset of BPD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004364	glutathione transferase activity	molecular function	IDA[10739172]	3
GO:0006749	glutathione metabolic process	biological process	IDA[10739172]	5

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006805	xenobiotic metabolic process	biological process	TAS	19
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	20
GO:0005829	cytosol	cellular component	TAS	223
GO:0016034	maleylacetoacetate isomerase activity	molecular function	EXP; IDA[10739172]	1
GO:0005739	mitochondrion	cellular component	ISS	75
GO:0006559	L-phenylalanine catabolic process	biological process	IEA; TAS	2
GO:0006572	tyrosine catabolic process	biological process	IEA	1
GO:0042803	protein homodimerization activity	molecular function	IPI[10739172]	71
GO:1901687	glutathione derivative biosynthetic process	biological process	TAS	6
GO:0055114	oxidation-reduction process	biological process	TAS[9396740]	43
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0004602	glutathione peroxidase activity	molecular function	TAS[9396740]	4
GO:0005515	protein binding	molecular function	IPI[17474147]	563

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in BDgene
hsa00982	Drug metabolism - cytochrome P450	6
hsa00643	Styrene degradation	1
hsa00980	Metabolism of xenobiotics by cytochrome P450	3

ID	Name	No. of Genes in BDgene	Brief Description
hsa00350	Tyrosine metabolism	8
hsa00480	Glutathione metabolism	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q24	chr14:67400000-78800000	1 (0/0/1)
14q24.1-q32.12	chr14:67400000-94200000	1 (0/0/1)
14q22-24	chr14:50400000-78800000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr14:77320884..77331597 View in gBrowse