Gene Report

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Basic Info

Approved Symbol	NAA38
Previous Symbol	LSMD1
Symbol Alias	MGC14151, PFAAP2
Approved Name	N(alpha)-acetyltransferase 38, NatC auxiliary subunit
Previous Name	LSM domain containing 1
Location	17p13.1
Position	chr17:7856685-7885238, -1
External Links	HGNC: 28212 Entrez Gene: 84316 Ensembl: ENSG00000183011
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		NAA38 has been implicated in Alzheimerâ€™s disease and neurodegenerative diseases.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0005737	cytoplasm	cellular component	IDA[19398576]	322
GO:0031417	NatC complex	cellular component	IDA[19398576]	1
GO:0043066	negative regulation of apoptotic process	biological process	IMP[19398576]	46
GO:0005844	polysome	cellular component	IDA[19398576]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 28)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NAA38	LSM7	NO	in vitro	11920408
NAA38	KCTD3	NO	yeast 2-hybrid	15231747
NAA38	LSM2	YES	in vitro;yeast 2-hybrid	11920408 , 15231747 , 14667819
NAA38	PGD	NO	yeast 2-hybrid	15231747
NAA38	SEPT5	NO	yeast 2-hybrid	15231747
NAA38	EXOSC10	NO	yeast 2-hybrid	15231747
NAA38	NAGK	NO	yeast 2-hybrid	15231747
NAA38	SNRPD1	NO	yeast 2-hybrid	15231747
NAA38	LSM3	NO	in vitro	11920408
NAA38	COL23A1	NO	yeast 2-hybrid	15231747
NAA38	RPL24	NO	yeast 2-hybrid	15231747
NAA38	UPF1	NO	yeast 2-hybrid	15231747
NAA38	EXOSC6	NO	yeast 2-hybrid	15231747
NAA38	FAM63A	NO	yeast 2-hybrid	15231747
NAA38	TALDO1	NO	yeast 2-hybrid	15231747
NAA38	LSM5	NO	in vitro	11920408
NAA38	ITSN2	NO	yeast 2-hybrid	15231747
NAA38	DCP1A	NO	yeast 2-hybrid	15231747
NAA38	RSL24D1	NO	yeast 2-hybrid	15231747
NAA38	LSM6	NO	in vitro	11920408
NAA38	MTHFR	YES	yeast 2-hybrid	15231747
NAA38	ISOC2	NO	yeast 2-hybrid	15231747
NAA38	FERMT3	NO	yeast 2-hybrid	15231747
NAA38	PDCD2	NO	yeast 2-hybrid	15231747
NAA38	IL28RA	NO	yeast 2-hybrid	15231747
NAA38	DBF4	NO	yeast 2-hybrid	15231747
NAA38	IGHMBP2	NO	yeast 2-hybrid	15231747
NAA38	THUMPD3	NO	yeast 2-hybrid	15231747

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17p13.1-17p12	chr17:6500000-16100000	1 (0/1/0)
17p13	chr17:0-10800000	3 (0/3/0)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr17:7856685..7885238 View in gBrowse