Gene Report

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Basic Info

Approved Symbol	PRPF18
Symbol Alias	hPrp18
Approved Name	pre-mRNA processing factor 18
Previous Name	PRP18 pre-mRNA processing factor 18 homolog (yeast), "PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)"
Location	10p12.33
Position	chr10:13586927-13630868, 1
External Links	HGNC: 17351 Entrez Gene: 8559 Ensembl: ENSG00000165630 UCSC: uc001imp.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs10906418	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008380	RNA splicing	biological process	IEA	8
GO:0005634	nucleus	cellular component	TAS[9000057]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016607	nuclear speck	cellular component	IEA	16
GO:0005681	spliceosomal complex	cellular component	IEA	6
GO:0019870	potassium channel inhibitor activity	molecular function	IEA	1
GO:0006397	mRNA processing	biological process	IEA	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PRPF18	PPIH	NO	in vitro;in vivo	11823439

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10906418	chr10:13591273 - 13591273(1)	downstream_gene_variant; intron_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs12360444		chr10:13594534 - 13594534(1)	intron_variant; upstream_gene_variant
rs11258465		chr10:13598931 - 13598931(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11-p14	chr10:6600000-39800000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10p13	chr10:12200000-17300000	2 (0/1/1)
10p13-p15	chr10:0-17300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:13586927..13630868 View in gBrowse