Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	SNAI1
Symbol Alias	SNA, SLUGH2, SNAH, SNAIL1, SNAIL
Approved Name	snail family zinc finger 1
Previous Name	snail 1 (drosophila homolog), zinc finger protein, "snail homolog 1 (Drosophila)"
Location	20q13.2
Position	chr20:49982999-49988886, 1
External Links	HGNC: 11128 Entrez Gene: 6615 Ensembl: ENSG00000124216 UCSC: uc002xuz.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.15. Encodes for a zinc finger transcriptional repressor which is involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 26)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[15448698]; ISS	283

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0060972	left/right pattern formation	biological process	IEA	2
GO:0001837	epithelial to mesenchymal transition	biological process	IDA[16096638]; ISS	3
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0010957	negative regulation of vitamin D biosynthetic process	biological process	IDA[19502595]	1
GO:0016477	cell migration	biological process	IEA	17
GO:0005515	protein binding	molecular function	IPI[15448698]	563
GO:2000810	regulation of tight junction assembly	biological process	IMP[15314165]	2
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IMP[20018240]	58
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	biological process	IMP[15314165]	2
GO:0031069	hair follicle morphogenesis	biological process	IEA	4
GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development	biological process	IEA	1
GO:0019900	kinase binding	molecular function	IPI[15448698]	8
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	IDA[11912130]	14
GO:0001707	mesoderm formation	biological process	ISS	2
GO:0060536	cartilage morphogenesis	biological process	IEA	1
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	biological process	IMP[15314165]	2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[11912130]; IMP[15314165]; ISS	62
GO:0001649	osteoblast differentiation	biological process	IEP[20128911]	9
GO:0010718	positive regulation of epithelial to mesenchymal transition	biological process	IMP[20018240]; TAS[17072303]	2
GO:0061314	Notch signaling involved in heart development	biological process	ISS	1
GO:0060021	palate development	biological process	IEA	6
GO:0060707	trophoblast giant cell differentiation	biological process	IEA	1
GO:0005737	cytoplasm	cellular component	IDA[15448698]; ISS	322
GO:0030335	positive regulation of cell migration	biological process	IMP[15314165]	16
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular function	IEA	10

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04520	Adherens junction	11

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
mta3Pathway	Downregulated of MTA-3 in ER-negative Breast Tumors	2

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SNAI1	CTDSP2	NO	in vitro;in vivo	19004823
SNAI1	CTDSPL	NO	in vitro;in vivo	19004823
SNAI1	CTDSP1	NO	in vitro;in vivo	19004823
SNAI1	GSK3B	YES	in vivo	19004823

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q13	chr20:43100000-64444167	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:49982999..49988886 View in gBrowse