Gene Report

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Basic Info

Approved Symbol	TRRAP
Symbol Alias	TR-AP, PAF400, Tra1
Approved Name	transformation/transcription domain-associated protein
Location	7q21.2-q22.1
Position	chr7:98877933-99013243, 1
External Links	HGNC: 12347 Entrez Gene: 8295 Ensembl: ENSG00000196367 UCSC: uc003upp.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs736624	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[9708738]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003713	transcription coactivator activity	molecular function	IEA	22
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0006325	chromatin organization	biological process	TAS	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	molecular function	IEA	2
GO:0016301	kinase activity	molecular function	IBA	7
GO:0000812	Swr1 complex	cellular component	IDA[24463511]	3
GO:0003712	transcription cofactor activity	molecular function	IDA[11418595]	4
GO:0043967	histone H4 acetylation	biological process	IDA[14966270]	4
GO:0016310	phosphorylation	biological process	IBA	9
GO:0005515	protein binding	molecular function	IPI[11415895]	563
GO:0030914	STAGA complex	cellular component	IDA[11564863]	1
GO:0016578	histone deubiquitination	biological process	IDA[18206972]	1
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0035267	NuA4 histone acetyltransferase complex	cellular component	IDA[10966108]	3
GO:0043968	histone H2A acetylation	biological process	IDA[14966270]	2
GO:0007093	mitotic cell cycle checkpoint	biological process	IEA	5
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0016573	histone acetylation	biological process	NAS[10966108]	5
GO:0006281	DNA repair	biological process	IBA	16
GO:0000125	PCAF complex	cellular component	NAS[9885574]	1
GO:0033276	transcription factor TFTC complex	cellular component	IDA[10373431]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
pitx2Pathway	Multi-step Regulation of Transcription by Pitx2	3

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRRAP	E2F4	NO	in vivo	11418595
TRRAP	MYC	NO	in vitro;in vivo	9708738
TRRAP	MAX	NO	in vitro	10611234
TRRAP	ATXN7	NO	in vivo	15115762
TRRAP	BRCA1	NO	in vitro;in vivo	16260778
TRRAP	E2F1	NO	in vivo	9708738
TRRAP	EP400	NO	in vitro;in vivo	11509179
TRRAP	KAT2A	NO	in vitro;in vivo	11931763
TRRAP	ACTL6A	NO	in vivo	11839798
TRRAP	C20orf20	NO	in vitro	12963728
TRRAP	BRD8	NO	in vitro;in vivo	12963728

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs736624	chr7:99010579 - 99010579(1)	intron_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
7q22	chr7:98400000-107800000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:98877933..99013243 View in gBrowse