Gene Report

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Basic Info

Approved Symbol	TRRAP
Symbol Alias	TR-AP, PAF400, Tra1
Approved Name	transformation/transcription domain-associated protein
Location	7q21.2-q22.1
Position	chr7:98877933-99013243, 1
External Links	HGNC: 12347 Entrez Gene: 8295 Ensembl: ENSG00000196367 UCSC: uc003upp.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs736624	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[9708738]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003713	transcription coactivator activity	molecular function	IEA	22
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0006325	chromatin organization	biological process	TAS	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	molecular function	IEA	2
GO:0016301	kinase activity	molecular function	IBA	7
GO:0000812	Swr1 complex	cellular component	IDA[24463511]	3
GO:0003712	transcription cofactor activity	molecular function	IDA[11418595]	4
GO:0043967	histone H4 acetylation	biological process	IDA[14966270]	4
GO:0016310	phosphorylation	biological process	IBA	9
GO:0005515	protein binding	molecular function	IPI[11415895]	563
GO:0030914	STAGA complex	cellular component	IDA[11564863]	1
GO:0016578	histone deubiquitination	biological process	IDA[18206972]	1
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0035267	NuA4 histone acetyltransferase complex	cellular component	IDA[10966108]	3
GO:0043968	histone H2A acetylation	biological process	IDA[14966270]	2
GO:0007093	mitotic cell cycle checkpoint	biological process	IEA	5
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0016573	histone acetylation	biological process	NAS[10966108]	5
GO:0006281	DNA repair	biological process	IBA	16
GO:0000125	PCAF complex	cellular component	NAS[9885574]	1
GO:0033276	transcription factor TFTC complex	cellular component	IDA[10373431]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
pitx2Pathway	Multi-step Regulation of Transcription by Pitx2	3

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRRAP	EP400	NO	in vitro;in vivo	11509179
TRRAP	E2F4	NO	in vivo	11418595
TRRAP	ATXN7	NO	in vivo	15115762
TRRAP	E2F1	NO	in vivo	9708738
TRRAP	ACTL6A	NO	in vivo	11839798
TRRAP	MAX	NO	in vitro	10611234
TRRAP	KAT2A	NO	in vitro;in vivo	11931763
TRRAP	C20orf20	NO	in vitro	12963728
TRRAP	BRCA1	NO	in vitro;in vivo	16260778
TRRAP	BRD8	NO	in vitro;in vivo	12963728
TRRAP	MYC	NO	in vitro;in vivo	9708738

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs736624	chr7:99010579 - 99010579(1)	intron_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
7q22	chr7:98400000-107800000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:98877933..99013243 View in gBrowse