Gene Report

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Basic Info

Approved Symbol	DDX27
Symbol Alias	dJ686N3.1, DRS1
Approved Name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Previous Name	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27
Location	20q13.13
Position	chr20:49219295-49244077, 1
External Links	HGNC: 15837 Entrez Gene: 55661 Ensembl: ENSG00000124228 UCSC: uc002xuh.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs238157	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005524	ATP binding	molecular function	IEA	118
GO:0004386	helicase activity	molecular function	IEA	4
GO:0008152	metabolic process	biological process	IEA	50
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DDX27	PPP1R16A	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs238157	chr20:49239695 - 49239695(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q13	chr20:43100000-64444167	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr20:49219295..49244077 View in gBrowse