Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ADARB1
Symbol Alias	ADAR2, DRADA2, ADAR2g, DRABA2, RED1, hRED1, ADAR2a-L1, ADAR2a-L2, ADAR2a-L3, ADAR2a, ADAR2b, ADAR2c, ADAR2d
Approved Name	adenosine deaminase, RNA-specific, B1
Previous Name	adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)
Name Alias	RED1 homolog (rat)
Location	21q22.3
Position	chr21:45073853-45226560, 1
External Links	HGNC: 226 Entrez Gene: 104 Ensembl: ENSG00000197381 UCSC: uc002zgt.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kostyrko, A., 2006	Other variant: ADARB1_c.2234A>G	According to our results, bipolar affective disorder may not be caused by mutations in ADARB1.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[8995285]	283
GO:0045087	innate immune response	biological process	IEA	49

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044822	poly(A) RNA binding	molecular function	IDA[22681889]	44
GO:0006397	mRNA processing	biological process	IEA	8
GO:0006396	RNA processing	biological process	IDA[9149227]	4
GO:0003729	mRNA binding	molecular function	TAS[9149227]	5
GO:0010467	gene expression	biological process	TAS	41
GO:0045070	positive regulation of viral genome replication	biological process	IMP[21289159]	1
GO:0051726	regulation of cell cycle	biological process	IDA[18178553]	6
GO:0005730	nucleolus	cellular component	IDA[18178553]	28
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0030336	negative regulation of cell migration	biological process	IDA[18178553]	12
GO:0051607	defense response to virus	biological process	IEA	6
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	biological process	IDA[21289159]	1
GO:0005515	protein binding	molecular function	IPI[21847096]	563
GO:0006382	adenosine to inosine editing	biological process	IDA[18178553]; TAS	1
GO:0003723	RNA binding	molecular function	IDA[9111310]	14
GO:0004000	adenosine deaminase activity	molecular function	IEA	1
GO:0008285	negative regulation of cell proliferation	biological process	IDA[18178553]	41
GO:0003725	double-stranded RNA binding	molecular function	IDA[8995285]	9
GO:0016553	base conversion or substitution editing	biological process	IC[9149227]	1
GO:0003726	double-stranded RNA adenosine deaminase activity	molecular function	IDA[8995285]	1
GO:0016556	mRNA modification	biological process	TAS	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ADARB1_c.2234A>G	point mutation	exon10	1 (0/1/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 21	chr21:0-46709983	1 (0/1/0)
21q22	chr21:30200000-46709983	2 (0/0/2)
21q21.3-qter	chr21:25500000-46709983	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr21:45073853..45226560 View in gBrowse