Gene Report

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Basic Info

Approved Symbol	SERPINA11
Approved Name	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
Previous Name	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
Location	14q32.13
Position	chr14:94442464-94452790, -1
External Links	HGNC: 19193 Entrez Gene: 256394 Ensembl: ENSG00000186910 UCSC: uc001ydd.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0027. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004867	serine-type endopeptidase inhibitor activity	molecular function	IBA	7

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005615	extracellular space	cellular component	IBA	85
GO:0010951	negative regulation of endopeptidase activity	biological process	IBA	10

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:94442464..94452790 View in gBrowse