Gene Report

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Basic Info

Approved Symbol	RLF
Symbol Alias	ZNF292L, Zn-15L
Approved Name	rearranged L-myc fusion
Previous Name	rearranged L-myc fusion sequence
Location	1p32
Position	chr1:40161373-40240921, 1
External Links	HGNC: 10025 Entrez Gene: 6018 Ensembl: ENSG00000117000 UCSC: uc001cfc.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs6670779	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	NAS[8545128]	83
GO:0005634	nucleus	cellular component	IC[8545128]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	ISS[8545128]	91
GO:0005515	protein binding	molecular function	IPI[10545207]	563
GO:0015074	DNA integration	biological process	IDA[1851085]	1
GO:0008270	zinc ion binding	molecular function	TAS[8545128]	77
GO:0006355	regulation of transcription, DNA-templated	biological process	NAS[8545128]	62
GO:0051276	chromosome organization	biological process	IDA[1649386]; NAS[8545128]	2
GO:0045893	positive regulation of transcription, DNA-templated	biological process	ISS[8545128]	58
GO:0006351	transcription, DNA-templated	biological process	IEA	103

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RLF	RIT2	YES	in vitro	10545207
RLF	PRPF40A	NO	yeast 2-hybrid	15231748
RLF	RIT1	NO	yeast 2-hybrid	10545207

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6670779	chr1:40191777 - 40191777(1)	intron_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p34.2	chr1:39600000-43700000	1 (0/0/1)
1p33-p36	chr1:0-50200000	1 (0/0/1)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr1:40161373..40240921 View in gBrowse